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Physiotherapy. 2014 Jun;100(2):100-7. doi: 10.1016/j.physio.2013.12.002. Epub 2014 Feb 12.

Effect of postoperative physical training on activity after curative surgery for non-small cell lung cancer: a multicentre randomised controlled trial.

Author information

1
NIHR Biomedical Research Centre, Guy's and St Thomas' Foundation Trust and Kings College London, UK.
2
NIHR Biomedical Research Centre, Guy's and St Thomas' Foundation Trust and Kings College London, UK; Division of Health and Social Care Research, King's College London, UK.
3
NIHR Respiratory Biomedical Research Unit at Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.
4
Centre for Exercise and Rehabilitation Science, University Hospitals of Leicester NHS Trust, Leicester, UK.
5
King's College London, Denmark Hill Campus, London, UK.
6
King's College London, Denmark Hill Campus, London, UK. Electronic address: rachel.garrod@nhs.net.

Abstract

OBJECTIVE:

To evaluate the effect of a combined hospital plus home exercise programme following curative surgery for non-small cell lung cancer (NSCLC).

DESIGN:

Randomised controlled trial.

SETTING:

Teaching hospital.

PARTICIPANTS:

One hundred and thirty-one subjects with NSCLC admitted for curative surgery.

INTERVENTIONS:

Participants were randomised to usual care or a hospital plus home exercise programme.

OUTCOMES:

The primary outcome was the between-group difference in physical activity 4 weeks after surgery. Secondary outcomes were the difference in quadriceps strength, exercise tolerance and quality of life [Short Form-36 (SF-36) and European Organisation for Research and Treatment of Cancer (EORTC) QLQ-LC13] from pre-operatively (baseline) to 4 weeks after surgery.

RESULTS:

The participants (n=131) had a mean age of 68 [standard deviation (SD) 11] years and mean forced expiratory volume in 1 second of 2.4 (SD 1.1)l. There were no significant differences in physical activity between the groups 4 weeks after surgery [mean difference adjusted for baseline 12minutes/day, 95% confidence interval (CI) -20.2 to 44.1]. In addition, there were no significant differences in total SF-36 or EORTC QLQ-LC13 scores from baseline to 4 weeks after surgery. Both groups had recovered their pre-operative walking distance 4 weeks after surgery, and there were no differences between the groups (mean difference in Incremental Shuttle Walk Test from baseline to 4 weeks after surgery (-26m, 95% CI -94.2 to 42.3).

CONCLUSIONS:

A hospital plus home exercise programme showed little benefit in unselected patients with NSCLC following surgery. Regardless of group allocation, the patients had recovered their pre-operative exercise tolerance levels by 4 weeks after surgery.

KEYWORDS:

Exercise; Non-small cell lung cancer; Surgery; Thoracotomy

PMID:
24703523
DOI:
10.1016/j.physio.2013.12.002
[Indexed for MEDLINE]

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