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Int J Paediatr Dent. 2016 Jan;26(1):35-44. doi: 10.1111/ipd.12155. Epub 2015 Feb 13.

Effect of maternal use of chewing gums containing xylitol on transmission of mutans streptococci in children: a meta-analysis of randomized controlled trials.

Lin HK1, Fang CE2, Huang MS1,3, Cheng HC4,5, Huang TW6, Chang HT1, Tam KW7,8,9,10,11.

Author information

1
Department of Dentistry, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
2
Department of Dentistry, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
3
Research Center for Biomedical Devices, Taipei Medical University, Taipei, Taiwan.
4
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
5
Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan.
6
Department of Nursing, College of Medicine and Nursing, HungKuang University, Taichung, Taiwan.
7
Department of Surgery, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
8
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
9
Center for Evidence-based Medicine, Taipei Medical University, Taipei, Taiwan.
10
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
11
Center for Evidence-based Health Care, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.

Abstract

BACKGROUND:

Mutans streptococci (MS) are the major causative bacteria involved in human dental decay. Habitual consumption of xylitol has been proved to reduce MS levels in saliva and plaque.

AIM:

To evaluate the effect of the maternal use of xylitol gum on MS reduction in infants.

DESIGN:

A structured literature review and meta-analysis. A random effects model was used to assess the relative risks of the incidence of MS in the saliva or plaque of children who were 6, 9, 12, 18, and 24 months old.

RESULTS:

We reviewed 11 RCTs derived from 5 research teams that included 601 mothers. Our results indicated that the incidence of MS in the saliva or plaque of the infants was significantly reduced in the xylitol group (risk ratio: 0.54; 95% confidence interval: 0.39-0.73, at 12-18 months) and (risk ratio: 0.56; 95% confidence interval: 0.40-0.79, at 36 months) compared with the control groups. The long-term effect of maternal xylitol gum exposure on their children's dental caries was controversial.

CONCLUSION:

Habitual xylitol consumption by mothers with high MS levels was associated with a significant reduction in the mother-child transmission of salivary MS.

PMID:
25684114
DOI:
10.1111/ipd.12155
[Indexed for MEDLINE]

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