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Ophthalmic Surg Lasers Imaging Retina. 2016 Mar;47(3):238-44. doi: 10.3928/23258160-20160229-06.

Effect of Fluid Status at Week 12 on Visual and Anatomic Outcomes at Week 52 in the VIEW 1 and 2 Trials.

Abstract

BACKGROUND AND OBJECTIVE:

To evaluate effect of retinal fluid status at week 12 on visual and anatomic outcomes at week 52 in patients with neovascular age-related macular degeneration from the VIEW studies.

PATIENTS AND METHODS:

Post-hoc analysis included 1,465 eyes treated with intravitreal aflibercept (Eylea; Regeneron, Tarrytown, NY) 2 mg every 4 weeks (2q4) or every 8 weeks following three initial monthly injections (2q8) or ranibizumab (Lucentis; Genentech, South San Francisco, CA) 0.5 mg every 4 weeks (Rq4), which had known retinal fluid status at weeks 12 and 52.

RESULTS:

At 12 weeks, 512 (35%) eyes had fluid and 953 (65%) were fluid-free. Two hundred three (41.5%), 148 (29.8%), and 161 (33.5%) eyes had fluid in Rq4, 2q4, and 2q8, respectively. Best-corrected visual acuity (BCVA) change at week 52 from baseline was independent of retinal fluid status at week 12 or treatment assignment. Eyes were more likely to remain fluid-free at week 52 if absent of fluid at week 12.

CONCLUSION:

At week 52, 2q4, 2q8, and Rq4 improved BCVA independent of fluid status at week 12.

PMID:
26985797
DOI:
10.3928/23258160-20160229-06
[Indexed for MEDLINE]

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