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Acta Neurol Scand. 2001 Nov;104(5):288-95.

Early TNF-alpha levels correlate with ischaemic stroke severity.

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1
Department of Clinical Neuroimmunology, University School of Medicine, Poznan, Poland.

Abstract

OBJECTIVES:

The study aimed to evaluate the levels of an important proinflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) in cerebrospinal fluid (CSF) and serum in acute stroke and to study the relation between those and the neurological stroke severity and functional disability.

MATERIAL AND METHODS:

The investigations comprised 23 ischaemic stroke patients. CSF and blood samples were obtained 24 h after the onset of stroke, and stored until analysis. Patients were examined according to Scandinavian Stroke Scale (SSS) and to Barthel Index (BI).

RESULTS:

The patients displayed statistically significant high levels of TNF-alpha in CSF and sera within the first 24 h of stroke. These correlated significantly with SSS and BI scores calculated within the same interval, and 1 and 2 weeks later.

CONCLUSION:

Our results suggest the involvement of TNF-alpha in mechanisms of early stroke-induced inflammation and a predictive value of the initial TNF-alpha levels for the outcome of stroke.

PMID:
11696023
[Indexed for MEDLINE]

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