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80 results

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Page 1
eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.
Zhang Y, Wan X, Yang X, Liu X, Huang Q, Zhou L, Zhang S, Liu S, Xiong Q, Wei M, Qiu L, Zhang B, Han J. Zhang Y, et al. J Biol Chem. 2023 Sep;299(9):105177. doi: 10.1016/j.jbc.2023.105177. Epub 2023 Aug 21. J Biol Chem. 2023. PMID: 37611825 Free PMC article.
Here, we show that eIF3i is significantly increased in colorectal cancer (CRC) and reinforces the proliferation of CRC cells. ...In addition, knocking down eIF3i and PHGDH impedes tumor growth in vivo. Collectively, this study not only uncovered a novel regulatory m …
Here, we show that eIF3i is significantly increased in colorectal cancer (CRC) and reinforces the proliferation of CRC cells. ...In a …
eIF3i regulation of protein synthesis, cell proliferation, cell cycle progression, and tumorigenesis.
Ma S, Dong Z, Cui Q, Liu JY, Zhang JT. Ma S, et al. Cancer Lett. 2021 Mar 1;500:11-20. doi: 10.1016/j.canlet.2020.12.009. Epub 2020 Dec 8. Cancer Lett. 2021. PMID: 33301799 Review.
eIF3i, a 36-kDa protein, is a putative subunit of the eIF3 complex important for translation initiation of mRNAs. ...Furthermore, eIF3i has been shown to bind to TGF-beta type II receptor and participate in TGF-beta signaling. ...
eIF3i, a 36-kDa protein, is a putative subunit of the eIF3 complex important for translation initiation of mRNAs. ...Furthermore, …
Circular RNA EIF3I promotes papillary thyroid cancer progression by interacting with AUF1 to increase Cyclin D1 production.
Yao X, Liu H, Wang Z, Lu F, Chen W, Feng Q, Miao Y, Zhang J, Wang Y, Chen Y, Xue L, Liu Y, Chen L, Zhang Q. Yao X, et al. Oncogene. 2023 Oct;42(43):3206-3218. doi: 10.1038/s41388-023-02830-3. Epub 2023 Sep 11. Oncogene. 2023. PMID: 37697064
Here, we found that hsa_circ_0011385, designated as circular eukaryotic translation initiation factor 3 subunit I (circEIF3I), preferentially localized in the cytoplasm of PTC cells and was more stable than its linear counterpart, EIF3I. Gain- and loss-of-function studies …
Here, we found that hsa_circ_0011385, designated as circular eukaryotic translation initiation factor 3 subunit I (circEIF3I), preferentiall …
Circ-EIF3I facilitates proliferation, migration, and invasion of lung cancer via regulating the activity of Wnt/beta-catenin pathway through the miR-1253/NOVA2 axis.
Chen T, Feng G, Xing Z, Gao X. Chen T, et al. Thorac Cancer. 2022 Nov;13(22):3133-3144. doi: 10.1111/1759-7714.14665. Epub 2022 Oct 4. Thorac Cancer. 2022. PMID: 36193788 Free PMC article.
Xenograft tumor was constructed to explore the function of circ-EIF3I on LC tumor growth. Circ-EIF3I was upregulated in LC tumor tissues and cells. ...Circ-EIF3I could sponge miR-1253, and miR-1253 inhibitor overturned the regulation of circ-EIF3I knoc …
Xenograft tumor was constructed to explore the function of circ-EIF3I on LC tumor growth. Circ-EIF3I was upregulated in LC tum …
Molecular and Structural Characterization of Lenalidomide-Mediated Sequestration of eIF3i.
Lin Z, Shen D, Yang B, Woo CM. Lin Z, et al. ACS Chem Biol. 2022 Nov 18;17(11):3229-3237. doi: 10.1021/acschembio.2c00706. Epub 2022 Nov 3. ACS Chem Biol. 2022. PMID: 36325969 Free PMC article.
Here, we characterize the structural basis and mechanistic outcomes of lenalidomide-induced sequestration of eIF3i from the eIF3 complex. Identification of the binding interface on eIF3i by a covalent lenalidomide probe and mass spectrometry rationalizes the sequest …
Here, we characterize the structural basis and mechanistic outcomes of lenalidomide-induced sequestration of eIF3i from the eIF3 comp …
Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma.
Wang YW, Lin KT, Chen SC, Gu DL, Chen CF, Tu PH, Jou YS. Wang YW, et al. Hepatology. 2013 Jul;58(1):239-50. doi: 10.1002/hep.26352. Epub 2013 May 23. Hepatology. 2013. PMID: 23460382
A novel eIF3I and Akt1 protein interaction was identified in HCC cell lines and tissues and was required for eIF3I-mediated activation of Akt1 signaling. ...Treatment of eIF3I overexpressing HCC cells with the Akt1 specific inhibitor API-2 suppressed eIF3I …
A novel eIF3I and Akt1 protein interaction was identified in HCC cell lines and tissues and was required for eIF3I-mediated ac …
Circ-EIF3I Promotes Hepatocellular Carcinoma Progression Through Modulating miR-361-3p/DUSP2 Axis.
Ni L, Gao Q, Zhao Q, Dai K, Jin M, Fu C, Xiao M, Zhu W, Bi Y. Ni L, et al. DNA Cell Biol. 2024 Mar 22. doi: 10.1089/dna.2023.0400. Online ahead of print. DNA Cell Biol. 2024. PMID: 38513057
In addition, in vivo tumorigenesis and metastasis assays were employed to evaluate the roles of circ-EIF3I in HCC. The result shows that the circ-EIF3I expression was increased in HCC cell line, which means that circ-EIF3I plays a role in the progression of H …
In addition, in vivo tumorigenesis and metastasis assays were employed to evaluate the roles of circ-EIF3I in HCC. The result shows t …
EIF3i affects vesicular stomatitis virus growth by interacting with matrix protein.
Pan W, Song D, He W, Lu H, Lan Y, Li H, Gao F, Zhao K. Pan W, et al. Vet Microbiol. 2017 Dec;212:59-66. doi: 10.1016/j.vetmic.2017.10.021. Epub 2017 Nov 7. Vet Microbiol. 2017. PMID: 29173589 Free PMC article.
VSV transcription was increased at 4h post-infection but was not changed at 8 and 12h post-infection after the over-expression of eIF3i. Finally, we also demonstrated that VSV could inhibit the activity of Akt1 and that the knockdown of eIF3i inhibited the expressio …
VSV transcription was increased at 4h post-infection but was not changed at 8 and 12h post-infection after the over-expression of eIF3i …
PD-L1 Triggered by Binding eIF3I Contributes to the Amelioration of Diabetes-Associated Wound Healing Defects by Regulating IRS4.
Kuai L, Xiang YW, Chen QL, Ru Y, Yin SY, Li W, Jiang JS, Luo Y, Song JK, Lu B, Luo Y, Li B. Kuai L, et al. J Invest Dermatol. 2022 Jan;142(1):220-231.e8. doi: 10.1016/j.jid.2021.06.028. Epub 2021 Jul 20. J Invest Dermatol. 2022. PMID: 34293353 Free article.
Mechanistically, PD-L1 binds to eIF3I and promotes cutaneous diabetic wound healing by downregulating IRS4. These findings identify that the eIF3I-PD-L1-IRS4 axis contributes to wound healing defects, which can serve as a potential therapeutic target in DUs....
Mechanistically, PD-L1 binds to eIF3I and promotes cutaneous diabetic wound healing by downregulating IRS4. These findings identify t …
eIF3i activity is critical for endothelial cells in tumor induced angiogenesis through regulating VEGFR and ERK translation.
Zhang Y, Wang P, Zhang Q, Yao X, Zhao L, Liu Y, Liu X, Tao R, Yu C, Li Y, Song X, Yao S. Zhang Y, et al. Oncotarget. 2017 Mar 21;8(12):19968-19979. doi: 10.18632/oncotarget.15274. Oncotarget. 2017. PMID: 28193911 Free PMC article.
Knockdown of eIF3i restrained cell proliferation and migration in endothelial cells. In zebrafish angiogenesis model, eIF3i mutant endothelial cells could not respond to induction signals from tumor mass. ...
Knockdown of eIF3i restrained cell proliferation and migration in endothelial cells. In zebrafish angiogenesis model, eIF3i mu …
80 results