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Items: 1 to 20 of 86


Methylation Tolerance-based Functional Assay to Assess Variants of Unknown Significance in the MLH1 and MSH2 Genes and Identify Patients With Lynch Syndrome.

Bouvet D, Bodo S, Munier A, Guillerm E, Bertrand R, Colas C, Duval A, Coulet F, Muleris M.

Gastroenterology. 2019 Apr 15. pii: S0016-5085(19)35707-5. doi: 10.1053/j.gastro.2019.03.071. [Epub ahead of print]


Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer-Beyond the Misdiagnosis-In Reply.

Cohen R, Duval A, Svrcek M.

JAMA Oncol. 2019 Apr 11. doi: 10.1001/jamaoncol.2019.0536. [Epub ahead of print] No abstract available.


Pancreatic ductal adenocarcinoma harboring microsatellite instability / DNA mismatch repair deficiency. Towards personalized medicine.

Lupinacci RM, Bachet JB, André T, Duval A, Svrcek M.

Surg Oncol. 2019 Mar;28:121-127. doi: 10.1016/j.suronc.2018.11.019. Epub 2018 Nov 26. Review.


MSI/MMR-deficient tumor diagnosis: Which standard for screening and for diagnosis? Diagnostic modalities for the colon and other sites: Differences between tumors.

Svrcek M, Lascols O, Cohen R, Collura A, Jonchère V, Fléjou JF, Buhard O, Duval A.

Bull Cancer. 2019 Feb;106(2):119-128. doi: 10.1016/j.bulcan.2018.12.008. Epub 2019 Feb 1. Review.


[Lynch syndrome: What is new?]

Pellat A, Netter J, Perkins G, Cohen R, Coulet F, Parc Y, Svrcek M, Duval A, André T.

Bull Cancer. 2018 Dec 4. pii: S0007-4551(18)30359-X. doi: 10.1016/j.bulcan.2018.10.009. [Epub ahead of print] Review. French.


Association of Primary Resistance to Immune Checkpoint Inhibitors in Metastatic Colorectal Cancer With Misdiagnosis of Microsatellite Instability or Mismatch Repair Deficiency Status.

Cohen R, Hain E, Buhard O, Guilloux A, Bardier A, Kaci R, Bertheau P, Renaud F, Bibeau F, Fléjou JF, André T, Svrcek M, Duval A.

JAMA Oncol. 2018 Nov 15. doi: 10.1001/jamaoncol.2018.4942. [Epub ahead of print]


Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability.

Bokhari A, Jonchere V, Lagrange A, Bertrand R, Svrcek M, Marisa L, Buhard O, Greene M, Demidova A, Jia J, Adriaenssens E, Chassat T, Biard DS, Flejou JF, Lejeune F, Duval A, Collura A.

Oncogenesis. 2018 Sep 19;7(9):70. doi: 10.1038/s41389-018-0079-x.


Identification of Positively and Negatively Selected Driver Gene Mutations Associated With Colorectal Cancer With Microsatellite Instability.

Jonchere V, Marisa L, Greene M, Virouleau A, Buhard O, Bertrand R, Svrcek M, Cervera P, Goloudina A, Guillerm E, Coulet F, Landman S, Ratovomanana T, Job S, Ayadi M, Elarouci N, Armenoult L, Merabtene F, Dumont S, Parc Y, Lefèvre JH, André T, Fléjou JF, Guilloux A, Collura A, de Reyniès A, Duval A.

Cell Mol Gastroenterol Hepatol. 2018 Jun 13;6(3):277-300. doi: 10.1016/j.jcmgh.2018.06.002. eCollection 2018.


mTOR and Tumor Cachexia.

Duval AP, Jeanneret C, Santoro T, Dormond O.

Int J Mol Sci. 2018 Jul 30;19(8). pii: E2225. doi: 10.3390/ijms19082225. Review.


Improved Microsatellite Instability Detection and Identification by Nuclease-Assisted Microsatellite Instability Enrichment Using HSP110 T17.

Baudrin LG, Duval A, Daunay A, Buhard O, Bui H, Deleuze JF, How-Kit A.

Clin Chem. 2018 Aug;64(8):1252-1253. doi: 10.1373/clinchem.2018.287490. Epub 2018 Jun 14. No abstract available.


Major improvement in the detection of microsatellite instability in colorectal cancer using HSP110 T17 E-ice-COLD-PCR.

How-Kit A, Daunay A, Buhard O, Meiller C, Sahbatou M, Collura A, Duval A, Deleuze JF.

Hum Mutat. 2018 Mar;39(3):441-453. doi: 10.1002/humu.23379. Epub 2017 Dec 26.


Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Lupinacci RM, Goloudina A, Buhard O, Bachet JB, Maréchal R, Demetter P, Cros J, Bardier-Dupas A, Collura A, Cervera P, Scriva A, Dumont S, Hammel P, Sauvanet A, Louvet C, Delpéro JR, Paye F, Vaillant JC, André T, Closset J, Emile JF, Van Laethem JL, Jonchère V, Abd Alsamad I, Antoine M, Rodenas A, Fléjou JF, Dusetti N, Iovanna J, Duval A, Svrcek M.

Gastroenterology. 2018 Mar;154(4):1061-1065. doi: 10.1053/j.gastro.2017.11.009. Epub 2017 Nov 20.


Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency.

Cohen R, Buhard O, Cervera P, Hain E, Dumont S, Bardier A, Bachet JB, Gornet JM, Lopez-Trabada D, Dumont S, Kaci R, Bertheau P, Renaud F, Bibeau F, Parc Y, Vernerey D, Duval A, Svrcek M, André T.

Eur J Cancer. 2017 Nov;86:266-274. doi: 10.1016/j.ejca.2017.09.022. Epub 2017 Oct 19.


The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.

Marisa L, Svrcek M, Collura A, Becht E, Cervera P, Wanherdrick K, Buhard O, Goloudina A, Jonchère V, Selves J, Milano G, Guenot D, Cohen R, Colas C, Laurent-Puig P, Olschwang S, Lefèvre JH, Parc Y, Boige V, Lepage C, André T, Fléjou JF, Dérangère V, Ghiringhelli F, de Reynies A, Duval A.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx136.


Immunotherapy and patients treated for cancer with microsatellite instability.

Colle R, Cohen R, Cochereau D, Duval A, Lascols O, Lopez-Trabada D, Afchain P, Trouilloud I, Parc Y, Lefevre JH, Fléjou JF, Svrcek M, André T.

Bull Cancer. 2017 Jan;104(1):42-51. doi: 10.1016/j.bulcan.2016.11.006. Epub 2016 Dec 13. Review.


Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors.

Faes S, Duval AP, Planche A, Uldry E, Santoro T, Pythoud C, Stehle JC, Horlbeck J, Letovanec I, Riggi N, Demartines N, Dormond O.

Mol Cancer. 2016 Dec 5;15(1):78.


HSP110 promotes colorectal cancer growth through STAT3 activation.

Berthenet K, Bokhari A, Lagrange A, Marcion G, Boudesco C, Causse S, De Thonel A, Svrcek M, Goloudina AR, Dumont S, Hammann A, Biard DS, Demidov ON, Seigneuric R, Duval A, Collura A, Jego G, Garrido C.

Oncogene. 2017 Apr 20;36(16):2328-2336. doi: 10.1038/onc.2016.403. Epub 2016 Nov 7.


Extracellular HSP110 skews macrophage polarization in colorectal cancer.

Berthenet K, Boudesco C, Collura A, Svrcek M, Richaud S, Hammann A, Causse S, Yousfi N, Wanherdrick K, Duplomb L, Duval A, Garrido C, Jego G.

Oncoimmunology. 2016 Apr 22;5(7):e1170264. doi: 10.1080/2162402X.2016.1170264. eCollection 2016 Jul.


New Therapeutic Opportunities Based on DNA Mismatch Repair and BRAF Status in Metastatic Colorectal Cancer.

Cohen R, Svrcek M, Dreyer C, Cervera P, Duval A, Pocard M, Fléjou JF, de Gramont A, André T.

Curr Oncol Rep. 2016 Mar;18(3):18. doi: 10.1007/s11912-016-0504-2. Review.


HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer.

Buhard O, Lagrange A, Guilloux A, Colas C, Chouchène M, Wanherdrick K, Coulet F, Guillerm E, Dorard C, Marisa L, Bokhari A, Greene M, El-Murr N, Bodo S, Muleris M, Sourouille I, Svrcek M, Cervera P, Blanché H, Lefevre JH, Parc Y, Lepage C, Chapusot C, Bouvier AM, Gaub MP, Selves J, Garrett K, Iacopetta B, Soong R, Hamelin R, Garrido C, Lascols O, André T, Fléjou JF, Collura A, Duval A.

J Med Genet. 2016 Jun;53(6):377-84. doi: 10.1136/jmedgenet-2015-103518. Epub 2016 Feb 1.


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