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Schizophr Res. 2018 Sep;199:226-234. doi: 10.1016/j.schres.2018.03.004. Epub 2018 Mar 21.

Disrupted network cross talk, hippocampal dysfunction and hallucinations in schizophrenia.

Author information

1
Neuroscience Institute, Georgia State University, Atlanta, GA, USA. Electronic address: share1@student.gsu.edu.
2
Department of Psychology, Georgia State University, Atlanta, GA, USA.
3
Psychiatry Service, San Francisco VA Medical Center, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: judith.ford@ucsf.edu.
4
Psychiatry Service, San Francisco VA Medical Center, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: Daniel.Mathalon@ucsf.edu.
5
Mind Research Network, Albuquerque, NM, USA. Electronic address: edamaraju@mrn.org.
6
Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA. Electronic address: JBustillo@salud.unm.edu.
7
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA. Electronic address: abelger@med.unc.edu.
8
Department of Computer Science and Engineering, Chonbuk National University, Jeonju, Republic of Korea. Electronic address: hlee@chonbuk.ac.kr.
9
Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA. Electronic address: muell093@umn.edu.
10
Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA; GRECC, Minneapolis VA Medical Center, Minneapolis, MN, USA. Electronic address: kolim@umn.edu.
11
Department of Psychiatry, University of California, San Diego, San Diego, CA, USA. Electronic address: gbrown@ucsd.edu.
12
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA. Electronic address: apreda@uci.edu.
13
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA. Electronic address: tvanerp@uci.edu.
14
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA. Electronic address: sgpotkin@uci.edu.
15
Mind Research Network, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA. Electronic address: vcalhoun@mrn.org.
16
Neuroscience Institute, Georgia State University, Atlanta, GA, USA; Department of Psychology, Georgia State University, Atlanta, GA, USA; Mind Research Network, Albuquerque, NM, USA. Electronic address: jturner@mrn.org.

Abstract

Hallucinations characterize schizophrenia, with approximately 59% of patients reporting auditory hallucinations and 27% reporting visual hallucinations. Prior neuroimaging studies suggest that hallucinations are linked to disrupted communication across distributed (sensory, salience-monitoring and subcortical) networks. Yet, our understanding of the neurophysiological mechanisms that underlie auditory and visual hallucinations in schizophrenia remains limited. This study integrates two resting-state functional magnetic resonance imaging (fMRI) analysis methods - amplitudes of low-frequency fluctuations (ALFF) and functional network connectivity (FNC) - to explore the hypotheses that (1) abnormal FNC between salience and sensory (visual/auditory) networks underlies hallucinations in schizophrenia, and (2) disrupted hippocampal oscillations (as measured by hippocampal ALFF) beget changes in FNC linked to hallucinations. Our first hypothesis was supported by the finding that schizophrenia patients reporting hallucinations have higher FNC between the salience network and an associative auditory network relative to healthy controls. Hippocampal ALFF was negatively associated with FNC between primary auditory cortex and the salience network in healthy subjects, but was positively associated with FNC between these networks in patients reporting hallucinations. These findings provide indirect support favoring our second hypothesis. We suggest future studies integrate fMRI with electroencephalogram (EEG) and/or magnetoencephalogram (MEG) methods to directly probe the temporal relation between altered hippocampal oscillations and changes in cross-network functional communication.

KEYWORDS:

ALFF; FNC; Hallucinations; Resting-state; fMRI

PMID:
29571753
PMCID:
PMC6148405
[Available on 2019-09-01]
DOI:
10.1016/j.schres.2018.03.004

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