Format

Send to

Choose Destination

See 1 citation found using an alternative search:

See comment in PubMed Commons below
Br J Ophthalmol. 2013 Mar;97(3):323-6. doi: 10.1136/bjophthalmol-2012-302561. Epub 2013 Jan 3.

Molecular testing prognostic of low risk in epithelioid uveal melanoma in a child.

Author information

1
Division of Hematology/ Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Abstract

AIMS:

To characterise a histologically unusual paediatric uveal melanoma by gene expression and karyotypic profiling and assess prognosis.

METHODS:

The tumour was studied by histopathology, karyotype analysis, single nucleotide polymorphism and gene expression profile analysis for correlation with clinical outcome.

RESULTS:

The tumour had predominantly epithelioid histology. Karyotype analysis showed none of the poor prognosis features normally associated with uveal melanoma. single nucleotide polymorphism analysis revealed no imbalance at chromosome 3. Gene expression profiling indicated low risk disease.

CONCLUSIONS:

We report a child remaining relapse-free 6 years after diagnosis of a very rare uveal melanoma, with poor prognosis epithelioid histology, but gene expression profiling that accurately predicted low risk disease.

PMID:
23292925
PMCID:
PMC4966167
DOI:
10.1136/bjophthalmol-2012-302561
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center