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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1962 1
1964 2
1966 1
1967 3
1968 3
1969 2
1971 2
1972 2
1973 3
1974 2
1975 4
1976 3
1977 3
1978 5
1979 8
1980 3
1981 7
1982 3
1983 8
1984 4
1985 9
1986 4
1987 6
1988 9
1989 12
1990 13
1991 7
1992 17
1993 12
1994 10
1995 12
1996 14
1997 14
1998 23
1999 14
2000 25
2001 11
2002 24
2003 11
2004 18
2005 14
2006 18
2007 18
2008 17
2009 23
2010 31
2011 29
2012 29
2013 31
2014 25
2015 32
2016 38
2017 46
2018 52
2019 55
2020 77
2021 81
2022 102
2023 108
2024 32

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1,101 results

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Page 1
Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase.
Zhan M, Ding Y, Huang S, Liu Y, Xiao J, Yu H, Lu L, Wang X. Zhan M, et al. Nat Commun. 2023 May 30;14(1):3123. doi: 10.1038/s41467-023-38753-6. Nat Commun. 2023. PMID: 37253718 Free PMC article.
Metabolic adenylate kinase 2 (AK2) directly phosphorylates LOXL3-S704. Phosphorylated LOXL3-S704 targets dihydroorotate dehydrogenase (DHODH) and stabilizes it by preventing its ubiquitin-mediated proteasomal degradation. ...
Metabolic adenylate kinase 2 (AK2) directly phosphorylates LOXL3-S704. Phosphorylated LOXL3-S704 targets dihydroorotate dehydrogen …
Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer.
Boukalova S, Hubackova S, Milosevic M, Ezrova Z, Neuzil J, Rohlena J. Boukalova S, et al. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165759. doi: 10.1016/j.bbadis.2020.165759. Epub 2020 Mar 6. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32151633 Free article. Review.
Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. ...
Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RN …
Dihydroorotate dehydrogenase inhibitors in anti-infective drug research.
Boschi D, Pippione AC, Sainas S, Lolli ML. Boschi D, et al. Eur J Med Chem. 2019 Dec 1;183:111681. doi: 10.1016/j.ejmech.2019.111681. Epub 2019 Sep 12. Eur J Med Chem. 2019. PMID: 31557612 Review.
As many parasitic organisms lack pyrimidine salvage pathways for pyrimidine nucleotides, blocking de novo biosynthesis is seen as an effective therapeutic means to selectively target the parasite without effecting the human host. Dihydroorotate dehydrogenase (DHODH) …
As many parasitic organisms lack pyrimidine salvage pathways for pyrimidine nucleotides, blocking de novo biosynthesis is seen as an effecti …
Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53-ALOX15 signaling pathway.
Li D, Lu X, Xu G, Liu S, Gong Z, Lu F, Xia X, Jiang J, Wang H, Zou F, Ma X. Li D, et al. CNS Neurosci Ther. 2023 Jul;29(7):1923-1939. doi: 10.1111/cns.14150. Epub 2023 Mar 21. CNS Neurosci Ther. 2023. PMID: 36942513 Free PMC article.
Ferroptosis is a non-apoptotic type of cell death that has only recently been identified, which is marked primarily by iron-dependent and lipid-derived reactive oxygen species accumulation, and accompanied by morphological modifications such as mitochondrial atrophy and increase …
Ferroptosis is a non-apoptotic type of cell death that has only recently been identified, which is marked primarily by iron-dependent and li …
Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase.
Zhang S, Kang L, Dai X, Chen J, Chen Z, Wang M, Jiang H, Wang X, Bu S, Liu X, Zhang G, Tang H. Zhang S, et al. Free Radic Biol Med. 2022 Nov 20;193(Pt 1):202-212. doi: 10.1016/j.freeradbiomed.2022.10.004. Epub 2022 Oct 10. Free Radic Biol Med. 2022. PMID: 36228830 Free article.
In this study, we found that administration of MnCl(2) to tumor cells resulted in lipid peroxidation and increased the levels of mitochondrial ROS, consequently leading to ferroptosis. Dihydroorotate dehydrogenase (DHODH)-mediated ferroptosis defence is a targetable …
In this study, we found that administration of MnCl(2) to tumor cells resulted in lipid peroxidation and increased the levels of mitochondri …
Dihydroorotate dehydrogenase: A drug target for the development of antimalarials.
Singh A, Maqbool M, Mobashir M, Hoda N. Singh A, et al. Eur J Med Chem. 2017 Jan 5;125:640-651. doi: 10.1016/j.ejmech.2016.09.085. Epub 2016 Sep 27. Eur J Med Chem. 2017. PMID: 27721149 Review.
Beside this, various drugs that could inhibit the imperative enzymes of the parasite have also been reported. Amid them, dihydroorotate dehydrogenase (DHODH) has a key worth. DHODH is involved in the de novo pyrimidine biosynthesis of the malarial parasite which act …
Beside this, various drugs that could inhibit the imperative enzymes of the parasite have also been reported. Amid them, dihydroorotate …
Dihydroorotate dehydrogenase as a herbicide target.
Duke SO. Duke SO. Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2319097120. doi: 10.1073/pnas.2319097120. Epub 2023 Dec 12. Proc Natl Acad Sci U S A. 2023. PMID: 38085787 No abstract available.
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Mao C, et al. Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. Nature. 2021. PMID: 33981038 Free PMC article.
Here we show that treatment of cancer cells with GPX4 inhibitors results in acute depletion of N-carbamoyl-L-aspartate, a pyrimidine biosynthesis intermediate, with concomitant accumulation of uridine. Supplementation with dihydroorotate or orotate-the substrate and produc …
Here we show that treatment of cancer cells with GPX4 inhibitors results in acute depletion of N-carbamoyl-L-aspartate, a pyrimidine biosynt …
Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria.
Hoelz LV, Calil FA, Nonato MC, Pinheiro LC, Boechat N. Hoelz LV, et al. Future Med Chem. 2018 Aug 1;10(15):1853-1874. doi: 10.4155/fmc-2017-0250. Epub 2018 Jul 18. Future Med Chem. 2018. PMID: 30019917 Review.
In recent decades, the major challenge to treatment of this disease has been the ability of the protozoan parasite to develop resistance to the drugs that are currently in use. Among P. falciparum enzymes, P. falciparum dihydroorotate dehydrogenase has been identifi …
In recent decades, the major challenge to treatment of this disease has been the ability of the protozoan parasite to develop resistance to …
1,101 results