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Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.

Neckers L, Blagg B, Haystead T, Trepel JB, Whitesell L, Picard D.

Cell Stress Chaperones. 2018 Jul;23(4):467-482. doi: 10.1007/s12192-018-0877-2. Epub 2018 Feb 1.


Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol.

Abla N, Bashyam S, Charman SA, Greco B, Hewitt P, Jiménez-Díaz MB, Katneni K, Kubas H, Picard D, Sambandan Y, Sanz L, Smith D, Wang T, Willis P, Wittlin S, Spangenberg T.

ACS Med Chem Lett. 2017 Nov 28;8(12):1304-1308. doi: 10.1021/acsmedchemlett.7b00391. eCollection 2017 Dec 14.


Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry.

Wider D, Picard D.

PLoS One. 2017 Dec 8;12(12):e0189403. doi: 10.1371/journal.pone.0189403. eCollection 2017.


Dendrogenin A drives LXR to trigger lethal autophagy in cancers.

Segala G, David M, de Medina P, Poirot MC, Serhan N, Vergez F, Mougel A, Saland E, Carayon K, Leignadier J, Caron N, Voisin M, Cherier J, Ligat L, Lopez F, Noguer E, Rives A, Payré B, Saati TA, Lamaziere A, Despres G, Lobaccaro JM, Baron S, Demur C, de Toni F, Larrue C, Boutzen H, Thomas F, Sarry JE, Tosolini M, Picard D, Record M, Récher C, Poirot M, Silvente-Poirot S.

Nat Commun. 2017 Dec 4;8(1):1903. doi: 10.1038/s41467-017-01948-9.


Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.

Fitzgerald JC, Zimprich A, Carvajal Berrio DA, Schindler KM, Maurer B, Schulte C, Bus C, Hauser AK, Kübler M, Lewin R, Bobbili DR, Schwarz LM, Vartholomaiou E, Brockmann K, Wüst R, Madlung J, Nordheim A, Riess O, Martins LM, Glaab E, May P, Schenke-Layland K, Picard D, Sharma M, Gasser T, Krüger R.

Brain. 2017 Sep 1;140(9):2444-2459. doi: 10.1093/brain/awx202.


Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23.

Madon-Simon M, Grad I, Bayo P, Pérez P, Picard D.

PLoS One. 2017 Jun 26;12(6):e0180035. doi: 10.1371/journal.pone.0180035. eCollection 2017.


H2B monoubiquitination: t'ub or not t'ub for inducible enhancers.

Segala G, Picard D.

Transcription. 2017 Mar 15;8(2):126-132. doi: 10.1080/21541264.2017.1285852. Epub 2017 Feb 8.


Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.

Vartholomaiou E, Madon-Simon M, Hagmann S, Mühlebach G, Wurst W, Floss T, Picard D.

Oncotarget. 2017 Mar 14;8(11):17428-17442. doi: 10.18632/oncotarget.15659.


Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers.

Segala G, Bennesch MA, Pandey DP, Hulo N, Picard D.

Mol Cell. 2016 Oct 20;64(2):334-346. doi: 10.1016/j.molcel.2016.08.034. Epub 2016 Sep 29.


LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP.

Bennesch MA, Segala G, Wider D, Picard D.

Nucleic Acids Res. 2016 Oct 14;44(18):8655-8670. Epub 2016 Jun 20.


Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol-carbazoles.

Wang T, Mäser P, Picard D.

J Med Chem. 2016 Jul 14;59(13):6344-52. doi: 10.1021/acs.jmedchem.6b00591. Epub 2016 Jun 28.


GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response.

De Marco P, Lappano R, De Francesco EM, Cirillo F, Pupo M, Avino S, Vivacqua A, Abonante S, Picard D, Maggiolini M.

Sci Rep. 2016 Apr 13;6:24354. doi: 10.1038/srep24354.


Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis.

Vartholomaiou E, Echeverría PC, Picard D.

Adv Cancer Res. 2016;129:1-30. doi: 10.1016/bs.acr.2015.08.001. Epub 2015 Oct 23. Review.


A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation.

Echeverría PC, Briand PA, Picard D.

Mol Cell Biol. 2016 Mar 31;36(8):1310-21. doi: 10.1128/MCB.01099-15. Print 2016 Apr.


Minireview: Tipping the balance: ligand-independent activation of steroid receptors.

Bennesch MA, Picard D.

Mol Endocrinol. 2015 Mar;29(3):349-63. doi: 10.1210/me.2014-1315. Epub 2015 Jan 27. Review.


Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells.

Rasola A, Neckers L, Picard D.

Trends Cell Biol. 2014 Aug;24(8):455-63. doi: 10.1016/j.tcb.2014.03.005. Epub 2014 Apr 11. Review.


Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.

Wang T, Bisson WH, Mäser P, Scapozza L, Picard D.

J Med Chem. 2014 Mar 27;57(6):2524-35. doi: 10.1021/jm401801t. Epub 2014 Mar 3.


Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapy.

Fierro-Monti I, Echeverria P, Racle J, Hernandez C, Picard D, Quadroni M.

PLoS One. 2013 Nov 27;8(11):e80425. doi: 10.1371/journal.pone.0080425. eCollection 2013.

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