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BMJ. 2015 Nov 9;351:h5762. doi: 10.1136/bmj.h5762.

Diagnostic yield and accuracy of CT angiography, MR angiography, and digital subtraction angiography for detection of macrovascular causes of intracerebral haemorrhage: prospective, multicentre cohort study.

Author information

1
Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, PO box 85500, 3508 GA Utrecht, Netherlands c.j.j.vanasch@gmail.com.
2
Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
3
Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, PO box 85500, 3508 GA Utrecht, Netherlands.
4
Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, PO box 85500, 3508 GA Utrecht, Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
5
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands.
6
Department of Neurology, St Antonius Hospital, Nieuwegein, Netherlands.
7
Department of Neurology, St Elisabeth Hospital, Tilburg, Netherlands.
8
Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
9
Department of Neurology, Meander Medical Center, Amersfoort, Netherlands.
10
Department of Neurology, Rijnstate Hospital, Arnhem, Netherlands.
11
Department of Neurology, Leiden University Medical Center, Leiden, Netherlands.
12
Department of Neurology, Albert Schweitzer Hospital, Dordrecht, Netherlands.
13
Department of Neurology, MCH Westeinde, The Hague, Netherlands.
14
Department of Neurology, Flevo Hospital, Almere, Netherlands.
15
Department of Neurology, Amphia Hospital, Breda, Netherlands.
16
Department of Neurology, Gelre Hospital, Apeldoorn, Netherlands.
17
Department of Neurology, Tergooi Hospitals, Blaricum, Netherlands.
18
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
19
Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, PO box 85500, 3508 GA Utrecht, Netherlands Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands.

Abstract

STUDY QUESTION:

What are the diagnostic yield and accuracy of early computed tomography (CT) angiography followed by magnetic resonance imaging/angiography (MRI/MRA) and digital subtraction angiography (DSA) in patients with non-traumatic intracerebral haemorrhage?

METHODS:

This prospective diagnostic study enrolled 298 adults (18-70 years) treated in 22 hospitals in the Netherlands over six years. CT angiography was performed within seven days of haemorrhage. If the result was negative, MRI/MRA was performed four to eight weeks later. DSA was performed when the CT angiography or MRI/MRA results were inconclusive or negative. The main outcome was a macrovascular cause, including arteriovenous malformation, aneurysm, dural arteriovenous fistula, and cavernoma. Three blinded neuroradiologists independently evaluated the images for macrovascular causes of haemorrhage. The reference standard was the best available evidence from all findings during one year's follow-up.

STUDY ANSWER AND LIMITATIONS:

A macrovascular cause was identified in 69 patients (23%). 291 patients (98%) underwent CT angiography; 214 with a negative result underwent additional MRI/MRA and 97 with a negative result for both CT angiography and MRI/MRA underwent DSA. Early CT angiography detected 51 macrovascular causes (yield 17%, 95% confidence interval 13% to 22%). CT angiography with MRI/MRA identified two additional macrovascular causes (18%, 14% to 23%) and these modalities combined with DSA another 15 (23%, 18% to 28%). This last extensive strategy failed to detect a cavernoma, which was identified on MRI during follow-up (reference strategy). The positive predictive value of CT angiography was 72% (60% to 82%), of additional MRI/MRA was 35% (14% to 62%), and of additional DSA was 100% (75% to 100%). None of the patients experienced complications with CT angiography or MRI/MRA; 0.6% of patients who underwent DSA experienced permanent sequelae. Not all patients with negative CT angiography and MRI/MRA results underwent DSA. Although the previous probability of finding a macrovascular cause was lower in patients who did not undergo DSA, some small arteriovenous malformations or dural arteriovenous fistulas may have been missed.

WHAT THIS STUDY ADDS:

CT angiography is an appropriate initial investigation to detect macrovascular causes of non-traumatic intracerebral haemorrhage, but accuracy is modest. Additional MRI/MRA may find cavernomas or alternative diagnoses, but DSA is needed to diagnose macrovascular causes undetected by CT angiography or MRI/MRA.

FUNDING, COMPETING INTERESTS, DATA SHARING:

Dutch Heart Foundation and The Netherlands Organisation for Health Research and Development, ZonMw. The authors have no competing interests. Direct requests for additional data to the corresponding author.

PMID:
26553142
PMCID:
PMC4637845
[Indexed for MEDLINE]
Free PMC Article

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