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Cereb Cortex. 2017 Apr 1;27(4):2469-2485. doi: 10.1093/cercor/bhw095.

Development of Tract-Specific White Matter Pathways During Early Reading Development in At-Risk Children and Typical Controls.

Author information

1
Division of Developmental Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
2
Harvard Medical School, Boston, MA 02115, USA.
3
Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
4
Harvard Graduate School of Education, Cambridge, MA 02138, USA.

Abstract

Developmental dyslexia is a neurodevelopmental disorder with a strong genetic basis. Previous studies observed white matter alterations in the left posterior brain regions in adults and school-age children with dyslexia. However, no study yet has examined the development of tract-specific white matter pathways from the pre-reading to the fluent reading stage in children at familial risk for dyslexia (FHD+) versus controls (FHD-). This study examined white matter integrity at pre-reading, beginning, and fluent reading stages cross-sectionally ( n = 78) and longitudinally (n = 45) using an automated fiber-tract quantification method. Our findings depict white matter alterations and atypical lateralization of the arcuate fasciculus at the pre-reading stage in FHD+ versus FHD- children. Moreover, we demonstrate faster white matter development in subsequent good versus poor readers and a positive association between white matter maturation and reading development using a longitudinal design. Additionally, the combination of white matter maturation, familial risk, and psychometric measures best predicted later reading abilities. Furthermore, within FHD+ children, subsequent good readers exhibited faster white matter development in the right superior longitudinal fasciculus compared with subsequent poor readers, suggesting a compensatory mechanism. Overall, our findings highlight the importance of white matter pathway maturation in the development of typical and atypical reading skills.

KEYWORDS:

developmental dyslexia; familial risk; longitudinal; tractography; white matter development

PMID:
27114172
PMCID:
PMC5964366
DOI:
10.1093/cercor/bhw095
[Indexed for MEDLINE]
Free PMC Article

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