Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Mol Oncol. 2013 Jun;7(3):732-8. doi: 10.1016/j.molonc.2013.03.002. Epub 2013 Mar 26.

Development and validation of a microRNA-based diagnostic assay for classification of renal cell carcinomas.

Author information

1
Rosetta Genomics Ltd., Rehovot, Israel.

Abstract

Renal cancers account for more than 3% of adult malignancies and cause more than 13,000 deaths per year in the US alone. The four most common types of kidney tumors include the malignant renal cell carcinomas; clear cell, papillary, chromophobe and the benign oncocytoma. These histological subtypes vary in their clinical course and prognosis, and different clinical strategies have been developed for their management. In some kidney tumor cases it can be very difficult for the pathologist to distinguish between tumor types on the basis of morphology and immunohistochemistry (IHC). In this publication we present the development and validation of a microRNA-based assay for classifying primary kidney tumors. The assay, which classifies the four main kidney tumor types, was developed based on the expression of a set of 24 microRNAs. A validation set of 201 independent samples was classified using the assay and analyzed blindly. The assay produced results for 92% of the samples with an accuracy of 95%.

PMID:
23587442
PMCID:
PMC5528479
DOI:
10.1016/j.molonc.2013.03.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center