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Hypertens Pregnancy. 2017 May;36(2):217-225. doi: 10.1080/10641955.2017.1302470. Epub 2017 May 25.

Decreased frequency of peripheral blood CD8+CD25+FoxP3+regulatory T cells correlates with IL-33 levels in pre-eclampsia.

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a Department of Laboratory Medicine , Binhai County People's Hospital , Bianhai , Jiangsu Province , P. R. China.
b Department of Obstetrics and Gynecology , Binhai County People's Hospital , Bianhai , Jiangsu Province , P. R. China.



We aimed to investigate the role of CD8+CD25+Foxp3+regulatory T (Treg) cells in pre-eclampsia (PE).


This was a cross-sectional study of 46 patients with PE and 24 normotensive women within the third trimester of gestation. We analyzed the percentages of CD8+CD25+Foxp3+Treg cells in peripheral blood using flow cytometry and the serum levels of interleukin (IL)-6, IL-17A, IL-10, TGF-β1, IL-1β, and IL-33 by Luminex 200.


We found that patients with PE had lower percentages of CD8+CD25+Foxp3+Treg cells than normotensive pregnant women. In addition, the percentage of CD8+CD25+Foxp3+Treg cells was positively correlated with IL-33 concentration and negatively correlated with IL-17A concentration in patients with PE. We also found that IL-33 treatment can induce proliferation of CD8+CD25+Foxp3+Treg cells in vitro.


These findings suggest that the reduced CD8+CD25+Foxp3+Treg cells may play a role in the pathogenesis of PE. Abbreviations PE: pre-eclampsia; PBMCs: peripheral blood mononuclear cells; CTLA-4: cytotoxic T-lymphocyteantigen-4; APCs: antigen presenting cells; TGF-β: transforming growth factor-β; IL: interleukin; Treg: cells regulatory T cells; PBS: phosphate-buffered saline; Foxp3: forkhead Box protein 3; HELLPs: hemolysis, elevated liver enzyme and low platelet syndrome.


CD8+CD25+Foxp3+Treg; interleukin-33; pre-eclampsia

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