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Al18F-complexation of DFH17, a NOTA-conjugated adrenomedullin analog, for PET imaging of pulmonary circulation.

Alonso Martinez LM, Harel F, Nguyen QT, Létourneau M, D'Oliviera-Sousa C, Meloche B, Finnerty V, Fournier A, Dupuis J, DaSilva JN.

Nucl Med Biol. 2018 Oct 16;67:36-42. doi: 10.1016/j.nucmedbio.2018.10.003. [Epub ahead of print]


Simplified and robust one-step radiosynthesis of [18 F]DCFPyL via direct radiofluorination and cartridge-based purification.

Dornan MH, Simard JM, Leblond A, Juneau D, Delouya G, Saad F, Ménard C, DaSilva JN.

J Labelled Comp Radiopharm. 2018 May 2. doi: 10.1002/jlcr.3632. [Epub ahead of print]


Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging.

Ismail B, deKemp RA, Croteau E, Hadizad T, Burns KD, Beanlands RS, DaSilva JN.

PLoS One. 2017 May 19;12(5):e0177451. doi: 10.1371/journal.pone.0177451. eCollection 2017.


Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension.

Drozd K, Ahmadi A, Deng Y, Jiang B, Petryk J, Thorn S, Stewart D, Beanlands R, deKemp RA, DaSilva JN, Mielniczuk LM.

J Nucl Cardiol. 2017 Dec;24(6):1979-1989. doi: 10.1007/s12350-016-0663-4. Epub 2016 Sep 29.


Long-Term Follow-Up of Outcomes With F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction Secondary to Coronary Disease.

Mc Ardle B, Shukla T, Nichol G, deKemp RA, Bernick J, Guo A, Lim SP, Davies RA, Haddad H, Duchesne L, Hendry P, Masters R, Ross H, Freeman M, Gulenchyn K, Racine N, Humen D, Benard F, Ruddy TD, Chow BJ, Mielniczuk L, DaSilva JN, Garrard L, Wells GA, Beanlands RS; PARR-2 Investigators.

Circ Cardiovasc Imaging. 2016 Sep;9(9). pii: e004331. doi: 10.1161/CIRCIMAGING.115.004331.


Decreased renal AT1 receptor binding in rats after subtotal nephrectomy: PET study with [(18)F]FPyKYNE-losartan.

Ismail B, deKemp RA, Hadizad T, Mackasey K, Beanlands RS, DaSilva JN.

EJNMMI Res. 2016 Dec;6(1):55. doi: 10.1186/s13550-016-0209-4. Epub 2016 Jun 23.


Characterization of 18F-FPyKYNE-Losartan for Imaging AT1 Receptors.

Hachem M, Tiberi M, Ismail B, Hunter CR, Arksey N, Hadizad T, Beanlands RS, deKemp RA, DaSilva JN.

J Nucl Med. 2016 Oct;57(10):1612-1617. Epub 2016 May 19.


Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.

Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis AJ, Burgon PG.

J Biol Chem. 2015 Oct 30;290(44):26699-714. doi: 10.1074/jbc.M115.678433. Epub 2015 Sep 10.


Evaluation of [(11)C]methyl-losartan and [(11)C]methyl-EXP3174 for PET imaging of renal AT1receptor in rats.

Ismail B, Hadizad T, Antoun R, Lortie M, deKemp RA, Beanlands RS, DaSilva JN.

Nucl Med Biol. 2015 Nov;42(11):850-7. doi: 10.1016/j.nucmedbio.2015.06.012. Epub 2015 Jun 30.


Test-retest repeatability of myocardial blood flow and infarct size using ¹¹C-acetate micro-PET imaging in mice.

Croteau E, Renaud JM, McDonald M, Klein R, DaSilva JN, Beanlands RS, deKemp RA.

Eur J Nucl Med Mol Imaging. 2015 Sep;42(10):1589-600. doi: 10.1007/s00259-015-3111-9. Epub 2015 Jul 5.


Shifts in myocardial fatty acid and glucose metabolism in pulmonary arterial hypertension: a potential mechanism for a maladaptive right ventricular response.

Ohira H, deKemp R, Pena E, Davies RA, Stewart DJ, Chandy G, Contreras-Dominguez V, Dennie C, Mc Ardle B, Mc Klein R, Renaud JM, DaSilva JN, Pugliese C, Dunne R, Beanlands R, Mielniczuk LM.

Eur Heart J Cardiovasc Imaging. 2016 Dec;17(12):1424-1431. doi: 10.1093/ehjci/jev136. Epub 2015 Jun 9.


Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses.

Haley JM, Thackeray JT, Thorn SL, DaSilva JN.

PLoS One. 2015 May 21;10(5):e0127581. doi: 10.1371/journal.pone.0127581. eCollection 2015.


Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats.

Haley JM, Thackeray JT, Kolajova M, Thorn SL, DaSilva JN.

Life Sci. 2015 Jul 1;132:101-7. doi: 10.1016/j.lfs.2015.03.024. Epub 2015 Apr 28.


Development of reporter gene imaging techniques for long-term assessment of human circulating angiogenic cells.

Zhang Y, Kuraitis D, Burgon PG, Crowe S, Vulesevic B, Beanlands RS, deKemp RA, DaSilva JN, Ruel M, Suuronen EJ.

Biomed Mater. 2015 Mar 18;10(3):034104. doi: 10.1088/1748-6041/10/3/034104.


PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction.

Ahmadi A, Thorn SL, Alarcon EI, Kordos M, Padavan DT, Hadizad T, Cron GO, Beanlands RS, DaSilva JN, Ruel M, deKemp RA, Suuronen EJ.

Biomaterials. 2015 May;49:18-26. doi: 10.1016/j.biomaterials.2015.01.016. Epub 2015 Feb 11.


β2-adrenergic stress evaluation of coronary endothelial-dependent vasodilator function in mice using (11)C-acetate micro-PET imaging of myocardial blood flow and oxidative metabolism.

Croteau E, Renaud JM, Archer C, Klein R, DaSilva JN, Ruddy TD, Beanlands RS, deKemp RA.

EJNMMI Res. 2014 Dec 16;4(1):68. doi: 10.1186/s13550-014-0068-9. eCollection 2014 Dec.


N-[(11)C]-methyl-hydroxyfasudil is a potential biomarker of cardiac hypertrophy.

Moreau S, DaSilva JN, Valdivia A, Fernando P.

Nucl Med Biol. 2015 Feb;42(2):192-7. doi: 10.1016/j.nucmedbio.2014.09.008. Epub 2014 Sep 30.


Synthesis and evaluation of the novel 2-[¹⁸F]fluoro-3-propoxy-triazole-pyridine-substituted losartan for imaging AT₁ receptors.

Arksey N, Hadizad T, Ismail B, Hachem M, Valdivia AC, Beanlands RS, deKemp RA, DaSilva JN.

Bioorg Med Chem. 2014 Aug 1;22(15):3931-7. doi: 10.1016/j.bmc.2014.06.011. Epub 2014 Jun 17.


Effects of short-term continuous positive airway pressure on myocardial sympathetic nerve function and energetics in patients with heart failure and obstructive sleep apnea: a randomized study.

Hall AB, Ziadi MC, Leech JA, Chen SY, Burwash IG, Renaud J, deKemp RA, Haddad H, Mielniczuk LM, Yoshinaga K, Guo A, Chen L, Walter O, Garrard L, DaSilva JN, Floras JS, Beanlands RS.

Circulation. 2014 Sep 9;130(11):892-901. doi: 10.1161/CIRCULATIONAHA.113.005893. Epub 2014 Jul 3.


Early diabetes treatment does not prevent sympathetic dysinnervation in the streptozotocin diabetic rat heart.

Thackeray JT, deKemp RA, Beanlands RS, DaSilva JN.

J Nucl Cardiol. 2014 Aug;21(4):829-41. doi: 10.1007/s12350-014-9900-x. Epub 2014 Jun 3.


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