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Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

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Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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  • Nat Chem Biol. 2012 Mar;8(3):318.


The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.

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