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Year Number of Results
2002 1
2005 1
2007 1
2008 1
2009 2
2010 2
2012 3
2013 1
2014 2
2015 2
2016 2
2017 2
2018 5
2019 4
2020 8
2021 8
2022 10
2023 10
2024 2

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61 results

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Page 1
Role of mitochondrial metabolic disorder and immune infiltration in diabetic cardiomyopathy: new insights from bioinformatics analysis.
Peng C, Zhang Y, Lang X, Zhang Y. Peng C, et al. J Transl Med. 2023 Feb 1;21(1):66. doi: 10.1186/s12967-023-03928-8. J Transl Med. 2023. PMID: 36726122 Free PMC article.
Spearman analysis demonstrated that the hub MitoDEGs were positively associated with the infiltration of pro-inflammatory immune cells, but negatively associated with the infiltration of anti-inflammatory or regulatory immune cells. In the animal experiment, 4 hub MitoDEGs (Pdk4, …
Spearman analysis demonstrated that the hub MitoDEGs were positively associated with the infiltration of pro-inflammatory immune cells, but …
DECR1 directly activates HSL to promote lipolysis in cervical cancer cells.
Zhou H, Zhang J, Yan Z, Qu M, Zhang G, Han J, Wang F, Sun K, Wang L, Yang X. Zhou H, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159090. doi: 10.1016/j.bbalip.2021.159090. Epub 2021 Dec 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 34896618
We report that DECR1 overexpression significantly reduced the triglyceride (TAG) content in HeLa cells; conversely, DECR1 silencing increased intracellular TAG content. Subsequently, our experiments demonstrate that DECR1 promotes lipolysis via effects on hor …
We report that DECR1 overexpression significantly reduced the triglyceride (TAG) content in HeLa cells; conversely, DECR1 sile …
Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.
Nassar ZD, Mah CY, Dehairs J, Burvenich IJ, Irani S, Centenera MM, Helm M, Shrestha RK, Moldovan M, Don AS, Holst J, Scott AM, Horvath LG, Lynn DJ, Selth LA, Hoy AJ, Swinnen JV, Butler LM. Nassar ZD, et al. Elife. 2020 Jul 20;9:e54166. doi: 10.7554/eLife.54166. Elife. 2020. PMID: 32686647 Free PMC article.
DECR1 is a negatively-regulated androgen receptor (AR) target gene and, therefore, may promote PCa cell survival and resistance to AR targeting therapeutics. ...These findings implicate PUFA oxidation via DECR1 as an unexplored facet of FAO that promotes survival of …
DECR1 is a negatively-regulated androgen receptor (AR) target gene and, therefore, may promote PCa cell survival and resistance to AR …
DECR1 and ME1 genotypes are associated with lipid composition traits in Duroc pigs.
Ramírez O, Quintanilla R, Varona L, Gallardo D, Díaz I, Pena RN, Amills M. Ramírez O, et al. J Anim Breed Genet. 2014 Feb;131(1):46-52. doi: 10.1111/jbg.12035. Epub 2013 Apr 10. J Anim Breed Genet. 2014. PMID: 25099788
Variation at the porcine DECR1 and ME1 genes has been associated with meat quality traits and backfat thickness in Landrace pigs, respectively. ...At the within-family level, we found relevant associations between DECR1 and ME1 genotypes and diverse lipid compositio …
Variation at the porcine DECR1 and ME1 genes has been associated with meat quality traits and backfat thickness in Landrace pigs, res …
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, Blanco GR, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt SM, Zanivan S, Leung HY. Blomme A, et al. Nat Commun. 2020 May 19;11(1):2508. doi: 10.1038/s41467-020-16126-7. Nat Commun. 2020. PMID: 32427840 Free PMC article.
DECR1 knockout induces ER stress and sensitises CRPC cells to ferroptosis. In vivo, DECR1 deletion impairs lipid metabolism and reduces CRPC tumour growth, emphasizing the importance of DECR1 in the development of treatment resistance....
DECR1 knockout induces ER stress and sensitises CRPC cells to ferroptosis. In vivo, DECR1 deletion impairs lipid metabolism an …
Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.
Ursini-Siegel J, Rajput AB, Lu H, Sanguin-Gendreau V, Zuo D, Papavasiliou V, Lavoie C, Turpin J, Cianflone K, Huntsman DG, Muller WJ. Ursini-Siegel J, et al. Mol Cell Biol. 2007 Sep;27(18):6361-71. doi: 10.1128/MCB.00686-07. Epub 2007 Jul 16. Mol Cell Biol. 2007. PMID: 17636013 Free PMC article.
This correlates with a decreased proliferative index and reduced rates of de novo fatty acid synthesis in DecR1-expressing breast cancer cells. Although DecR1 expression does not affect glucose uptake in ErbB2/Neu-transformed cells, sustained expression of DecR1 …
This correlates with a decreased proliferative index and reduced rates of de novo fatty acid synthesis in DecR1-expressing breast can …
Roles of ferroptosis in urologic malignancies.
Zhao S, Li P, Wu W, Wang Q, Qian B, Li X, Shen M. Zhao S, et al. Cancer Cell Int. 2021 Dec 18;21(1):676. doi: 10.1186/s12935-021-02264-5. Cancer Cell Int. 2021. PMID: 34922551 Free PMC article. Review.
Mechanistically, a large number of biomolecules and tumor-associated signaling pathways, including DECR1, PANX2, HSPB1, ACOT8, SUV39H1, NCOA4, PI3K-AKT-mTOR signaling, VHL/HIF-2alpha pathway, and Hippo/TAZ signaling pathway, have been reported to regulate ferroptosis in ur …
Mechanistically, a large number of biomolecules and tumor-associated signaling pathways, including DECR1, PANX2, HSPB1, ACOT8, SUV39H …
Reduced 2,4-dienoyl-CoA reductase 1 is served as an unfavorable biomarker and is related to immune infiltration in cervical cancer.
Guo S, Jiang H, Deng Y, Dong Y, Yin A, Wang Q, Lan Q, Zhang Y, Xu C. Guo S, et al. J Obstet Gynaecol Res. 2023 Oct;49(10):2475-2486. doi: 10.1111/jog.15751. Epub 2023 Jul 27. J Obstet Gynaecol Res. 2023. PMID: 37497824
METHODS: Human Protein Atlas was used to identify the localization of DECR1. The Ualcan database, TCGA, and IHC were used to assess the prognostic value of DECR1. ...DECR1 was downregulated in CC compared to adjacent tissue. Survival analysis showed that pati …
METHODS: Human Protein Atlas was used to identify the localization of DECR1. The Ualcan database, TCGA, and IHC were used to assess t …
Association between ADSL, GARS-AIRS-GART, DGAT1, and DECR1 expression levels and pork meat quality traits.
Zhang XD, Zhang SJ, Ding YY, Feng YF, Zhu HY, Huang L, Wu T, Zhou J, Yin ZJ. Zhang XD, et al. Genet Mol Res. 2015 Nov 23;14(4):14823-30. doi: 10.4238/2015.November.18.47. Genet Mol Res. 2015. PMID: 26600543 Free article.
The association between expression of four genes (ADSL, GARS-AIRS-GART, DGAT1, and DECR1) and meat quality traits was also investigated. Meat quality traits were found to differ significantly between pig breeds. ...
The association between expression of four genes (ADSL, GARS-AIRS-GART, DGAT1, and DECR1) and meat quality traits was also investigat …
Polymorphism of the pig 2,4-dienoyl CoA reductase 1 gene (DECR1) and its association with carcass and meat quality traits.
Amills M, Vidal O, Varona L, Tomàs A, Gil M, Sànchez A, Noguera JL. Amills M, et al. J Anim Sci. 2005 Mar;83(3):493-8. doi: 10.2527/2005.833493x. J Anim Sci. 2005. PMID: 15705744
We characterized the nearly complete coding sequence of the pig 2,4-dienoyl CoA reductase 1 (DECR1) gene, which encodes an enzyme involved in the beta-oxidation of polyunsaturated fatty enoyl-CoA esters and maps on a linoleic QTL located on Chromosome 4. ...These two SNP a …
We characterized the nearly complete coding sequence of the pig 2,4-dienoyl CoA reductase 1 (DECR1) gene, which encodes an enzyme inv …
61 results