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Items: 1 to 20 of 35953

1.

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation.

Litton JK, Rugo HS, Ettl J, Hurvitz SA, Gonçalves A, Lee KH, Fehrenbacher L, Yerushalmi R, Mina LA, Martin M, Roché H, Im YH, Quek RGW, Markova D, Tudor IC, Hannah AL, Eiermann W, Blum JL.

N Engl J Med. 2018 Aug 15. doi: 10.1056/NEJMoa1802905. [Epub ahead of print]

PMID:
30110579
2.

Efficient and regioselective synthesis of γ-lactone glycosides through a novel debenzylative cyclization reaction.

Delbrouck JA, Tikad A, Vincent SP.

Chem Commun (Camb). 2018 Aug 15. doi: 10.1039/c8cc05523h. [Epub ahead of print]

PMID:
30110026
3.

Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity.

Nedopekina DA, Gubaidullin RR, Odinokov VN, Maximchik PV, Zhivotovsky B, Bel'skii YP, Khazanov VA, Manuylova AV, Gogvadze V, Spivak AY.

Medchemcomm. 2017 Sep 13;8(10):1934-1945. doi: 10.1039/c7md00248c. eCollection 2017 Oct 1.

PMID:
30108714
4.

Kub5-Hera RPRD1B deficiency promotes "BRCAness" and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers.

Motea EA, Fattah FJ, Xiao L, Girard L, Rommel A, Morales JC, Patidar P, Zhou Y, Porter A, Xie Y, Minna JD, Boothman DA.

Clin Cancer Res. 2018 Aug 14. pii: clincanres.1118.2017. doi: 10.1158/1078-0432.CCR-17-1118. [Epub ahead of print]

PMID:
30108102
5.

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.

Harp JM, Guenther DC, Bisbe A, Perkins L, Matsuda S, Bommineni GR, Zlatev I, Foster DJ, Taneja N, Charisse K, Maier MA, Rajeev KG, Manoharan M, Egli M.

Nucleic Acids Res. 2018 Aug 11. doi: 10.1093/nar/gky703. [Epub ahead of print]

PMID:
30107495
6.

Luteolin induces caspase-dependent apoptosis via inhibiting the AKT/osteopontin pathway in human hepatocellular carcinoma SK-Hep-1 cells.

Im E, Yeo C, Lee EO.

Life Sci. 2018 Aug 11. pii: S0024-3205(18)30471-5. doi: 10.1016/j.lfs.2018.08.025. [Epub ahead of print]

PMID:
30107166
7.

Synthesis of RNA Nucleotides in Plausible Prebiotic Conditions from ab initio Computer Simulations.

Pérez-Villa A, Saitta AM, Georgelin T, Lambert JF, Guyot F, Maurel MC, Pietrucci F.

J Phys Chem Lett. 2018 Aug 14. doi: 10.1021/acs.jpclett.8b02077. [Epub ahead of print]

PMID:
30107125
8.

Rucaparib in ovarian cancer: extending the use of PARP inhibitors in the recurrent disease.

Dal Molin GZ, Westin SN, Coleman RL.

Future Oncol. 2018 Aug 14. doi: 10.2217/fon-2018-0215. [Epub ahead of print]

PMID:
30105925
9.

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.

Chen Q, Kassab MA, Dantzer F, Yu X.

Nat Commun. 2018 Aug 13;9(1):3233. doi: 10.1038/s41467-018-05588-5.

PMID:
30104678
10.

Synthesis and Preliminary Evaluation of Biological Activity of Glycoconjugates Analogues of Acyclic Uridine Derivatives.

Komor R, Pastuch-Gawolek G, Krol E, Szeja W.

Molecules. 2018 Aug 13;23(8). pii: E2017. doi: 10.3390/molecules23082017.

11.

BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population.

Cardoso FC, Goncalves S, Mele PG, Liria NC, Sganga L, Diaz Perez I, Podesta EJ, Solano AR.

Hum Genomics. 2018 Aug 13;12(1):39. doi: 10.1186/s40246-018-0171-5.

12.

6-Chloropurine Ribonucleosides from Chloropyrimidines: One-Pot Synthesis.

Zelli R, Zeinyeh W, Décout JL.

Curr Protoc Nucleic Acid Chem. 2018 Aug 13:e57. doi: 10.1002/cpnc.57. [Epub ahead of print]

PMID:
30102466
13.

Double methylation of tRNA-U54 to 2'-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7.

Keller P, Freund I, Marchand V, Bec G, Huang R, Motorin Y, Eigenbrod T, Dalpke A, Helm M.

Nucleic Acids Res. 2018 Aug 8. doi: 10.1093/nar/gky644. [Epub ahead of print]

PMID:
30102387
14.

D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation.

Hong J, Wang X, Zhang N, Fu H, Li W.

Arch Pharm Res. 2018 Aug 13. doi: 10.1007/s12272-018-1061-z. [Epub ahead of print]

PMID:
30101366
15.

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors.

Lee SB, Segura-Bayona S, Villamor-Payà M, Saredi G, Todd MAM, Attolini CS, Chang TY, Stracker TH, Groth A.

Sci Adv. 2018 Aug 8;4(8):eaat4985. doi: 10.1126/sciadv.aat4985. eCollection 2018 Aug.

16.

Prosopis juliflora (Sw.), DC induces apoptosis and cell cycle arrest in triple negative breast cancer cells: in vitro and in vivo investigations.

Gurushidhappa UB, Shivajirao PM, Vasudeo NP, Shankar KS, Nivarti GR.

Oncotarget. 2018 Jul 13;9(54):30304-30323. doi: 10.18632/oncotarget.25717. eCollection 2018 Jul 13.

17.

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization.

McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM.

Mol Cell. 2018 Jul 26. pii: S1097-2765(18)30549-5. doi: 10.1016/j.molcel.2018.07.002. [Epub ahead of print]

PMID:
30100264
18.

Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome.

Ghosh SG, Becker K, Huang H, Salazar TD, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG.

Am J Hum Genet. 2018 Jul 25. pii: S0002-9297(18)30237-4. doi: 10.1016/j.ajhg.2018.07.010. [Epub ahead of print]

PMID:
30100084
19.

Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target.

Haeussler K, Fritz-Wolf K, Reichmann M, Rahlfs S, Becker K.

J Mol Biol. 2018 Aug 8. pii: S0022-2836(18)30513-8. doi: 10.1016/j.jmb.2018.07.030. [Epub ahead of print]

PMID:
30098336
20.

Identifying Genomic Sites of ADP-Ribosylation Mediated by Specific Nuclear PARP Enzymes Using Click-ChIP.

Rogge RA, Gibson BA, Kraus WL.

Methods Mol Biol. 2018;1813:371-387. doi: 10.1007/978-1-4939-8588-3_25.

PMID:
30097881

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