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J Rheumatol. 2009 Jul;36(7):1460-3. doi: 10.3899/jrheum.081212. Epub 2009 Jun 16.

Autologous hematopoietic stem cell transplant in systemic sclerosis: quantitative high resolution computed tomography of the chest scoring.

Author information

1
Service de Médecine Interne, Hôpital Claude-Huriez, Université Lille 2, Lille, France.

Abstract

OBJECTIVE:

Using high resolution computed tomography (HRCT), to assess the lung involvement outcome after autologous hematopoietic stem cell transplant (AHSCT) in patients with scleroderma (systemic sclerosis, SSc).

METHODS:

HCRT scans prospectively performed before (n = 9 patients) and after (n = 47) AHSCT were blindly reviewed by 2 independent investigators using the Wells score.

RESULTS:

After a median 60 months' followup, the overall disease extent score from HCRT scans decreased from 10 (0-45) to 4 (0-36) (p = 0.04) 6 months after AHSCT, and thereafter increased up to 36 months and stabilized; the modified Rodnan skin score fell (p < 0.05).

CONCLUSION:

The extent of SSc lung involvement on HRCT rapidly but transiently regressed after AHSCT.

PMID:
19531757
DOI:
10.3899/jrheum.081212
[Indexed for MEDLINE]

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