Abstract
We report a stereoselective synthesis of the (25S)-cholestenoic-26-acids which are highly efficient ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans.
MeSH terms
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Animals
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / metabolism
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Cholestenes / chemical synthesis*
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Cholestenes / chemistry
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Cholestenes / metabolism
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Ergosterol / chemical synthesis*
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Ergosterol / chemistry
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Ergosterol / metabolism
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Receptors, Cytoplasmic and Nuclear / metabolism
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Stereoisomerism
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Substrate Specificity
Substances
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Caenorhabditis elegans Proteins
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Cholestenes
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DAF-12 protein, C elegans
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Receptors, Cytoplasmic and Nuclear
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cholestenoic acid
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dafachronic acid
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delta4-dafachronic acid
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delta7-dafachronic acid
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Ergosterol