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Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Fusté NP, Fernández-Hernández R, Cemeli T, Mirantes C, Pedraza N, Rafel M, Torres-Rosell J, Colomina N, Ferrezuelo F, Dolcet X, Garí E. Fusté NP, et al. Nat Commun. 2016 May 16;7:11581. doi: 10.1038/ncomms11581. Nat Commun. 2016. PMID: 27181366 Free PMC article.
Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1.Cdk4 expression promotes tumour growth and metastasis. ...Here, we show that the focal ad …
Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell …
Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms.
Fusté NP, Ferrezuelo F, Garí E. Fusté NP, et al. Mol Cell Oncol. 2016 Jun 27;3(5):e1203471. doi: 10.1080/23723556.2016.1203471. eCollection 2016. Mol Cell Oncol. 2016. PMID: 27857971 Free PMC article.
Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. Membrane …
Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a nove …
Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation.
Montalto FI, Giordano F, Chiodo C, Marsico S, Mauro L, Sisci D, Aquila S, Lanzino M, Panno ML, Andò S, De Amicis F. Montalto FI, et al. Cancers (Basel). 2019 Aug 17;11(8):1201. doi: 10.3390/cancers11081201. Cancers (Basel). 2019. PMID: 31426542 Free PMC article.
Progesterone-Receptor (PR) positivity is related with an enhanced response to breast cancer therapy, conversely cyclin D1 (CD1) is a retained marker of poor outcome. Herein, we demonstrate that hydroxyprogesterone (OHPg) through progesterone receptor B (PR-B) reduce …
Progesterone-Receptor (PR) positivity is related with an enhanced response to breast cancer therapy, conversely cyclin D1 (CD1 …