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Nanomedicine (Lond). 2015 May;10(10):1621-41. doi: 10.2217/nnm.15.16.

Cyclodextrin complexes for treatment improvement in infectious diseases.

Author information

1
2National Science Research Council (CONICET), Buenos Aires, Argentina.

Abstract

Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented.

KEYWORDS:

cyclodextrins; drug/cyclodextrin complex; infectious diseases; low physical stability; poor aqueous solubility

PMID:
26008196
DOI:
10.2217/nnm.15.16
[Indexed for MEDLINE]

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