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Sci China Life Sci. 2015 Aug;58(8):750-6. doi: 10.1007/s11427-015-4851-2. Epub 2015 Apr 19.

Cryo-electron microscopy for structural biology: current status and future perspectives.

Author information

1
School of Life Sciences, Tsinghua University, Beijing, 100084, China, hongweiwang@tsinghua.edu.cn.

Abstract

Recently, significant technical breakthroughs in both hardware equipment and software algorithms have enabled cryo-electron microscopy (cryo-EM) to become one of the most important techniques in biological structural analysis. The technical aspects of cryo-EM define its unique advantages and the direction of development. As a rapidly emerging field, cryo-EM has benefitted from highly interdisciplinary research efforts. Here we review the current status of cryo-EM in the context of structural biology and discuss the technical challenges. It may eventually merge structural and cell biology at multiple scales.

PMID:
25894285
DOI:
10.1007/s11427-015-4851-2
[Indexed for MEDLINE]

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