Send to

Choose Destination
  • The following term was not found in PubMed: Jun;11.
Prenat Diagn. 1991 Jun;11(6):377-80.

First-trimester maternal serum unconjugated oestriol and alpha-fetoprotein in fetal Down's syndrome.

Author information

Department of Psychiatry, University of California, Los Angeles.


Maternal sera (MS) taken from 1396 women prior to chorionic villus sampling at 9-12 menstrual weeks were assayed for unconjugated oestriol (uE3) and alpha-fetoprotein (AFP). Median levels increased by 41 and 26 per cent per week respectively in normal pregnancies. There were 32 pregnancies with a chromosome abnormality. The median MS uE3 and AFP were 0.73 and 0.75 multiples of the median (MoM) respectively in the ten cases of Down's syndrome (DS) but not decreased in the other abnormalities. These results suggest that both uE3 and AFP may be useful in identifying DS in the first trimester. Additional prospective studies are needed to confirm these findings.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center