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Items: 1 to 20 of 143


An Atypical Mechanism of Split Intein Molecular Recognition and Folding.

Stevens AJ, Sekar G, Gramespacher JA, Cowburn D, Muir TW.

J Am Chem Soc. 2018 Sep 19;140(37):11791-11799. doi: 10.1021/jacs.8b07334. Epub 2018 Sep 10.


Deciphering the "Fuzzy" Interaction of FG Nucleoporins and Transport Factors Using Small-Angle Neutron Scattering.

Sparks S, Temel DB, Rout MP, Cowburn D.

Structure. 2018 Mar 6;26(3):477-484.e4. doi: 10.1016/j.str.2018.01.010. Epub 2018 Feb 8.


Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex.

Hayama R, Sparks S, Hecht LM, Dutta K, Karp JM, Cabana CM, Rout MP, Cowburn D.

J Biol Chem. 2018 Mar 23;293(12):4555-4563. doi: 10.1074/jbc.AC117.001649. Epub 2018 Jan 26.


Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release.

Warren C, Matsui T, Karp JM, Onikubo T, Cahill S, Brenowitz M, Cowburn D, Girvin M, Shechter D.

Nat Commun. 2017 Dec 20;8(1):2215. doi: 10.1038/s41467-017-02308-3.


A promiscuous split intein with expanded protein engineering applications.

Stevens AJ, Sekar G, Shah NH, Mostafavi AZ, Cowburn D, Muir TW.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8538-8543. doi: 10.1073/pnas.1701083114. Epub 2017 Jul 24.


Integrating NOE and RDC using sum-of-squares relaxation for protein structure determination.

Khoo Y, Singer A, Cowburn D.

J Biomol NMR. 2017 Jul;68(3):163-185. doi: 10.1007/s10858-017-0108-7. Epub 2017 Jun 14.


Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.

Upla P, Kim SJ, Sampathkumar P, Dutta K, Cahill SM, Chemmama IE, Williams R, Bonanno JB, Rice WJ, Stokes DL, Cowburn D, Almo SC, Sali A, Rout MP, Fernandez-Martinez J.

Structure. 2017 Mar 7;25(3):434-445. doi: 10.1016/j.str.2017.01.006. Epub 2017 Feb 2.


Effects of FGFR2 kinase activation loop dynamics on catalytic activity.

Karp JM, Sparks S, Cowburn D.

PLoS Comput Biol. 2017 Feb 2;13(2):e1005360. doi: 10.1371/journal.pcbi.1005360. eCollection 2017 Feb.


Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling.

Liu D, Yuan Y, Xu R, Cowburn D.

Protein Cell. 2017 Jan;8(1):67-71. doi: 10.1007/s13238-016-0333-y. No abstract available.


Segmental Isotopic Labeling of Proteins for NMR Study Using Intein Technology.

Liu D, Cowburn D.

Methods Mol Biol. 2017;1495:131-145.


Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex.

Raveh B, Karp JM, Sparks S, Dutta K, Rout MP, Sali A, Cowburn D.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2489-97. doi: 10.1073/pnas.1522663113. Epub 2016 Apr 18.


Design of a Split Intein with Exceptional Protein Splicing Activity.

Stevens AJ, Brown ZZ, Shah NH, Sekar G, Cowburn D, Muir TW.

J Am Chem Soc. 2016 Feb 24;138(7):2162-5. doi: 10.1021/jacs.5b13528. Epub 2016 Feb 8.


Identification of Hydrophobic Interfaces in Protein-Ligand Complexes by Selective Saturation Transfer NMR Spectroscopy.

Ferrage F, Dutta K, Cowburn D.

Molecules. 2015 Dec 9;20(12):21992-9. doi: 10.3390/molecules201219824.


Anti-DNA antibody mediated catalysis is isotype dependent.

Xia Y, Eryilmaz E, Zhang Q, Cowburn D, Putterman C.

Mol Immunol. 2016 Jan;69:33-43. doi: 10.1016/j.molimm.2015.11.001. Epub 2015 Dec 1.


A peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigens.

Xia Y, Eryilmaz E, Der E, Pawar RD, Guo X, Cowburn D, Putterman C.

Clin Exp Immunol. 2016 Mar;183(3):369-79. doi: 10.1111/cei.12734. Epub 2015 Dec 8.


The molecular mechanism of nuclear transport revealed by atomic-scale measurements.

Hough LE, Dutta K, Sparks S, Temel DB, Kamal A, Tetenbaum-Novatt J, Rout MP, Cowburn D.

Elife. 2015 Sep 15;4. pii: e10027. doi: 10.7554/eLife.10027.


Erratum to: Correlation of chemical shifts predicted by molecular dynamics simulations for partially disordered proteins.

Karp JM, Eryilmaz E, Cowburn D.

J Biomol NMR. 2015 May;62(1):119. doi: 10.1007/s10858-015-9915-x. No abstract available.


Controlling lipid micelle stability using oligonucleotide headgroups.

Wilner SE, Sparks SE, Cowburn D, Girvin ME, Levy M.

J Am Chem Soc. 2015 Feb 18;137(6):2171-4. doi: 10.1021/ja512012m. Epub 2015 Feb 3.


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