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Items: 1 to 20 of 79

1.

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).

Ben Djoudi Ouadda A, Gauthier MS, Susan-Resiga D, Girard E, Essalmani R, Black M, Marcinkiewicz J, Forget D, Hamelin J, Evagelidis A, Ly K, Day R, Galarneau L, Corbin F, Coulombe B, Çaku A, Tagliabracci VS, Seidah NG.

Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):1996-2013. doi: 10.1161/ATVBAHA.119.313247. Epub 2019 Sep 5.

PMID:
31553664
2.

The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis.

Choquet K, Pinard M, Yang S, Moir RD, Poitras C, Dicaire MJ, Sgarioto N, Larivière R, Kleinman CL, Willis IM, Gauthier MS, Coulombe B, Brais B.

Mol Brain. 2019 Jun 20;12(1):59. doi: 10.1186/s13041-019-0479-7.

3.

Leukodystrophy-associated POLR3A mutations down-regulate the RNA polymerase III transcript and important regulatory RNA BC200.

Choquet K, Forget D, Meloche E, Dicaire MJ, Bernard G, Vanderver A, Schiffmann R, Fabian MR, Teichmann M, Coulombe B, Brais B, Kleinman CL.

J Biol Chem. 2019 May 3;294(18):7445-7459. doi: 10.1074/jbc.RA118.006271. Epub 2019 Mar 21.

4.

Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease.

Gauthier MS, Cloutier P, Coulombe B.

Adv Exp Med Biol. 2018;1106:25-36. doi: 10.1007/978-3-030-00737-9_3. Review.

PMID:
30484151
5.

How do our cells build their protein interactome?

Coulombe B, Cloutier P, Gauthier MS.

Nat Commun. 2018 Jul 27;9(1):2955. doi: 10.1038/s41467-018-05448-2.

6.

Posttranslational modification of proprotein convertase subtilisin/kexin type 9 is differentially regulated in response to distinct cardiometabolic treatments as revealed by targeted proteomics.

Gauthier MS, Awan Z, Bouchard A, Champagne J, Tessier S, Faubert D, Chabot K, Garneau PY, Rabasa-Lhoret R, Seidah NG, Ridker PM, Genest J, Coulombe B.

J Clin Lipidol. 2018 Jul - Aug;12(4):1027-1038. doi: 10.1016/j.jacl.2018.03.092. Epub 2018 Apr 3.

PMID:
29699916
7.

Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy.

Mendes MI, Gutierrez Salazar M, Guerrero K, Thiffault I, Salomons GS, Gauquelin L, Tran LT, Forget D, Gauthier MS, Waisfisz Q, Smith DEC, Simons C, van der Knaap MS, Marquardt I, Lemes A, Mierzewska H, Weschke B, Koehler W, Coulombe B, Wolf NI, Bernard G.

Am J Hum Genet. 2018 Apr 5;102(4):676-684. doi: 10.1016/j.ajhg.2018.02.011. Epub 2018 Mar 22.

8.

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation.

Houry WA, Bertrand E, Coulombe B.

Trends Biochem Sci. 2018 Jan;43(1):4-9. doi: 10.1016/j.tibs.2017.11.001. Epub 2017 Dec 5. Review.

PMID:
29203338
9.

Functional 5' UTR motif discovery with LESMoN: Local Enrichment of Sequence Motifs in biological Networks.

Lavallée-Adam M, Cloutier P, Coulombe B, Blanchette M.

Nucleic Acids Res. 2017 Oct 13;45(18):10415-10427. doi: 10.1093/nar/gkx751.

10.

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

Cloutier P, Poitras C, Durand M, Hekmat O, Fiola-Masson É, Bouchard A, Faubert D, Chabot B, Coulombe B.

Nat Commun. 2017 May 31;8:15615. doi: 10.1038/ncomms15615.

11.

Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation.

Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B.

Mol Brain. 2017 Apr 13;10(1):13. doi: 10.1186/s13041-017-0294-y.

12.

Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.

Thiffault I, Wolf NI, Forget D, Guerrero K, Tran LT, Choquet K, Lavallée-Adam M, Poitras C, Brais B, Yoon G, Sztriha L, Webster RI, Timmann D, van de Warrenburg BP, Seeger J, Zimmermann A, Máté A, Goizet C, Fung E, van der Knaap MS, Fribourg S, Vanderver A, Simons C, Taft RJ, Yates JR 3rd, Coulombe B, Bernard G.

Nat Commun. 2015 Jul 7;6:7623. doi: 10.1038/ncomms8623.

13.

Introduction for the Special Issue of METHODS on Detection and quantification of proteins in clinical samples by mass spectrometry.

Coulombe B, Gauthier MS.

Methods. 2015 Jun 15;81:1-2. doi: 10.1016/j.ymeth.2015.05.015. No abstract available.

PMID:
26040901
14.

Abnormal expression of RNA polymerase II-associated proteins in muscle of patients with myofibrillar myopathies.

Guglielmi V, Marini M, Masson ÉF, Malatesta M, Forget D, Tomelleri G, Coulombe B, Vattemi G.

Histopathology. 2015 Dec;67(6):859-65. doi: 10.1111/his.12715. Epub 2015 May 25.

PMID:
25891782
15.

A semi-automated mass spectrometric immunoassay coupled to selected reaction monitoring (MSIA-SRM) reveals novel relationships between circulating PCSK9 and metabolic phenotypes in patient cohorts.

Gauthier MS, Pérusse JR, Awan Z, Bouchard A, Tessier S, Champagne J, Krastins B, Byram G, Chabot K, Garneau P, Rabasa-Lhoret R, Faubert D, Lopez MF, Seidah NG, Coulombe B.

Methods. 2015 Jun 15;81:66-73. doi: 10.1016/j.ymeth.2015.03.003. Epub 2015 Mar 11.

PMID:
25770357
16.

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.

Durcan TM, Tang MY, Pérusse JR, Dashti EA, Aguileta MA, McLelland GL, Gros P, Shaler TA, Faubert D, Coulombe B, Fon EA.

EMBO J. 2014 Nov 3;33(21):2473-91. doi: 10.15252/embj.201489729. Epub 2014 Sep 12.

17.

Increased subcutaneous adipose tissue expression of genes involved in glycerolipid-fatty acid cycling in obese insulin-resistant versus -sensitive individuals.

Gauthier MS, Pérusse JR, Lavoie MÈ, Sladek R, Madiraju SR, Ruderman NB, Coulombe B, Prentki M, Rabasa-Lhoret R.

J Clin Endocrinol Metab. 2014 Dec;99(12):E2518-28. doi: 10.1210/jc.2014-1662.

18.

Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.

Cloutier P, Lavallée-Adam M, Faubert D, Blanchette M, Coulombe B.

J Proteomics. 2014 Apr 4;100:115-24. doi: 10.1016/j.jprot.2013.10.008. Epub 2013 Oct 16.

PMID:
24140279
19.

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.

20.

Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2.

Forget D, Lacombe AA, Cloutier P, Lavallée-Adam M, Blanchette M, Coulombe B.

Nucleic Acids Res. 2013 Aug;41(14):6881-91. doi: 10.1093/nar/gkt455. Epub 2013 May 30.

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