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Sci Rep. 2015 Jul 8;5:11899. doi: 10.1038/srep11899.

Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease.

Author information

1
1] Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, 1854, Argentina [2] National Scientific and Technical Research Council (CONICET), Buenos Aires, 1033 Argentina [3] UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Diego Portales University, Santiago, 8370076, Chile.
2
Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, 1854, Argentina.
3
1] National Scientific and Technical Research Council (CONICET), Buenos Aires, 1033 Argentina [2] National University La Plata, Physics Institute, (IFLP-CCT-CONICET) La Plata, 1900, Argentina [3] Physics Department, Universitat de les Illes Balears, Palma de Mallorca, 07122, Spain.
4
SISTEMIC, Engineering Faculty, Universidad de Antioquia (UDEA), Medellín, 1226, Colombia.
5
Department of Research, Instituto de Alta Tecnología Médica de Antioquia, Medellín, 1234, Colombia.
6
Neuroscience Group, Faculty of Medicine, University of Antioquia (UDEA), Medellín, 1226, Colombia.
7
1] Group of Neuropsychology and Conduct (GRUNECO), Faculty of Medicine, University of Antioquia (UDEA), Medellín,1226, Colombia [2] Neuroscience Group, Faculty of Medicine, University of Antioquia (UDEA), Medellín, 1226, Colombia.
8
1] Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, 1854, Argentina [2] National Scientific and Technical Research Council (CONICET), Buenos Aires, 1033 Argentina [3] UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Diego Portales University, Santiago, 8370076, Chile [4] Faculty of Elementary and Special Education (FEEyE), National University of Cuyo (UNCuyo), Mendoza, 5502, Argentina.
9
1] Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, 1854, Argentina [2] National Scientific and Technical Research Council (CONICET), Buenos Aires, 1033 Argentina [3] UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Diego Portales University, Santiago, 8370076, Chile [4] Centre of Excellence in Cognition and its Disorders, Australian Research Council (ACR), New South Wales, 2109, Australia.
10
1] Mental Health Group. School of Public Health. Universidad de Antioquia (UDEA), Medellín, 1226, Colombia [2] Group of Neuropsychology and Conduct (GRUNECO), Faculty of Medicine, University of Antioquia (UDEA), Medellín,1226, Colombia [3] Neuroscience Group, Faculty of Medicine, University of Antioquia (UDEA), Medellín, 1226, Colombia.
11
1] Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, 1854, Argentina [2] National Scientific and Technical Research Council (CONICET), Buenos Aires, 1033 Argentina [3] UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Diego Portales University, Santiago, 8370076, Chile [4] Universidad Autónoma del Caribe, Barranquilla, 1234, Colombia [5] Centre of Excellence in Cognition and its Disorders, Australian Research Council (ACR), New South Wales, 2109, Australia.

Abstract

Impairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished ACE in EPD reflects a cortico-subcortical disruption, and recent neurocognitive models highlight the role of the basal ganglia (BG) in motor-language coupling. Building on such breakthroughs, we report the first exploration of convergent cortical and subcortical signatures of ACE in EPD patients and matched controls. Specifically, we combined cortical recordings of the motor potential, functional connectivity measures, and structural analysis of the BG through voxel-based morphometry. Relative to controls, EPD patients exhibited an impaired ACE, a reduced motor potential, and aberrant frontotemporal connectivity. Furthermore, motor potential abnormalities during the ACE task were predicted by overall BG volume and atrophy. These results corroborate that motor-language coupling is mainly subserved by a cortico-subcortical network including the BG as a key hub. They also evince that action-verb processing may constitute a neurocognitive marker of EPD. Our findings suggest that research on the relationship between language and motor domains is crucial to develop models of motor cognition as well as diagnostic and intervention strategies.

PMID:
26152329
PMCID:
PMC4495549
DOI:
10.1038/srep11899
[Indexed for MEDLINE]
Free PMC Article

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