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Page 1
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, Syed A, El-Sakkary N, Caffrey CR, Gamarro F, Ruiz-Perez LM, Gonzalez Pacanowska D, Ferrins L, Navarro M, Pollastri MP. Klug DM, et al. Among authors: cordon obras c. J Med Chem. 2021 Jul 8;64(13):9404-9430. doi: 10.1021/acs.jmedchem.1c00674. Epub 2021 Jun 22. J Med Chem. 2021. PMID: 34156862 Free PMC article.
Strasseriolides display in vitro and in vivo activity against trypanosomal parasites and cause morphological and size defects in Trypanosoma cruzi.
Bosch-Navarrete C, Pérez-Moreno G, Annang F, Diaz-Gonzalez R, García-Hernández R, Rocha H, Gamarro F, Cordón-Obras C, Navarro M, Rodriguez A, Genilloud O, Reyes F, Vicente F, Ruiz-Pérez LM, González-Pacanowska D. Bosch-Navarrete C, et al. Among authors: cordon obras c. PLoS Negl Trop Dis. 2023 Sep 15;17(9):e0011592. doi: 10.1371/journal.pntd.0011592. eCollection 2023 Sep. PLoS Negl Trop Dis. 2023. PMID: 37713416 Free PMC article.
Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis.
Tear WF, Bag S, Diaz-Gonzalez R, Ceballos-Pérez G, Rojas-Barros DI, Cordon-Obras C, Pérez-Moreno G, García-Hernández R, Martinez-Martinez MS, Ruiz-Perez LM, Gamarro F, Gonzalez Pacanowska D, Caffrey CR, Ferrins L, Manzano P, Navarro M, Pollastri MP. Tear WF, et al. Among authors: cordon obras c. J Med Chem. 2020 Jan 23;63(2):756-783. doi: 10.1021/acs.jmedchem.9b01741. Epub 2020 Jan 8. J Med Chem. 2020. PMID: 31846577 Free PMC article.
Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?
Amata E, Xi H, Colmenarejo G, Gonzalez-Diaz R, Cordon-Obras C, Berlanga M, Manzano P, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Navarro M, Pollastri MP. Amata E, et al. Among authors: cordon obras c. ACS Infect Dis. 2016 Mar 11;2(3):180-186. doi: 10.1021/acsinfecdis.5b00136. Epub 2016 Jan 17. ACS Infect Dis. 2016. PMID: 26998514 Free PMC article.
14 results