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  • The following term was not found in PubMed: Brain-De.
J Nat Prod. 2016 Sep 23;79(9):2264-9. doi: 10.1021/acs.jnatprod.6b00371. Epub 2016 Sep 2.

Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.

Author information

1
Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7, 38124 Braunschweig, Germany.
2
German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig , 38124 Braunschweig, Germany.
3
Zoological Institute, Technical University of Braunschweig , Spielmannstraße 7, 38106 Braunschweig, Germany.

Abstract

Three new natural products, corallocins A-C (1-3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.

PMID:
27588730
DOI:
10.1021/acs.jnatprod.6b00371
[Indexed for MEDLINE]

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