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Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.
Hartwig C, Méndez GM, Bhattacharjee S, Vrailas-Mortimer AD, Zlatic SA, Freeman AAH, Gokhale A, Concilli M, Werner E, Sapp Savas C, Rudin-Rush S, Palmer L, Shearing N, Margewich L, McArthy J, Taylor S, Roberts B, Lupashin V, Polishchuk RS, Cox DN, Jorquera RA, Faundez V. Hartwig C, et al. Among authors: concilli m. J Neurosci. 2021 Jan 13;41(2):215-233. doi: 10.1523/JNEUROSCI.1284-20.2020. Epub 2020 Nov 18. J Neurosci. 2021. PMID: 33208468 Free PMC article.
Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis.
Polishchuk EV, Concilli M, Iacobacci S, Chesi G, Pastore N, Piccolo P, Paladino S, Baldantoni D, van IJzendoorn SC, Chan J, Chang CJ, Amoresano A, Pane F, Pucci P, Tarallo A, Parenti G, Brunetti-Pierri N, Settembre C, Ballabio A, Polishchuk RS. Polishchuk EV, et al. Among authors: concilli m. Dev Cell. 2014 Jun 23;29(6):686-700. doi: 10.1016/j.devcel.2014.04.033. Epub 2014 Jun 5. Dev Cell. 2014. PMID: 24909901 Free PMC article.
Activation of Autophagy, Observed in Liver Tissues From Patients With Wilson Disease and From ATP7B-Deficient Animals, Protects Hepatocytes From Copper-Induced Apoptosis.
Polishchuk EV, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova EY, Concilli M, De Cegli R, Crispino R, Mariniello M, Petruzzelli R, Ranucci G, Iorio R, Pietrocola F, Einer C, Borchard S, Zibert A, Schmidt HH, Di Schiavi E, Puchkova LV, Franco B, Kroemer G, Zischka H, Polishchuk RS. Polishchuk EV, et al. Among authors: concilli m. Gastroenterology. 2019 Mar;156(4):1173-1189.e5. doi: 10.1053/j.gastro.2018.11.032. Epub 2018 Nov 17. Gastroenterology. 2019. PMID: 30452922
Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants.
Chesi G, Hegde RN, Iacobacci S, Concilli M, Parashuraman S, Festa BP, Polishchuk EV, Di Tullio G, Carissimo A, Montefusco S, Canetti D, Monti M, Amoresano A, Pucci P, van de Sluis B, Lutsenko S, Luini A, Polishchuk RS. Chesi G, et al. Among authors: concilli m. Hepatology. 2016 Jun;63(6):1842-59. doi: 10.1002/hep.28398. Epub 2016 Jan 25. Hepatology. 2016. PMID: 26660341 Free PMC article.
The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.
Fieten H, Gill Y, Martin AJ, Concilli M, Dirksen K, van Steenbeek FG, Spee B, van den Ingh TS, Martens EC, Festa P, Chesi G, van de Sluis B, Houwen RH, Watson AL, Aulchenko YS, Hodgkinson VL, Zhu S, Petris MJ, Polishchuk RS, Leegwater PA, Rothuizen J. Fieten H, et al. Among authors: concilli m. Dis Model Mech. 2016 Jan;9(1):25-38. doi: 10.1242/dmm.020263. Dis Model Mech. 2016. PMID: 26747866 Free PMC article.