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Mol Biol Cell. 2018 Apr 15;29(8):937-947. doi: 10.1091/mbc.E17-11-0622. Epub 2018 Mar 30.

Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins.

Author information

1
Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
2
Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35924.

Abstract

Cold temperature blocks used to synchronize protein trafficking inhibit GBF1 function, leading to a decrease in ARF1-GTP levels and mislocalization of the ARF1 effector golgin-160. Several other, but not all, Golgi proteins including ARL1 also mislocalize. ARF1 activity and golgin-160 localization require more than 30 min to recover from these blocks.

PMID:
29467256
PMCID:
PMC5896932
DOI:
10.1091/mbc.E17-11-0622
[Indexed for MEDLINE]
Free PMC Article

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