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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
2002 4
2003 4
2004 3
2005 4
2006 8
2007 4
2008 11
2009 7
2010 15
2011 16
2012 18
2013 20
2014 31
2015 28
2016 36
2017 44
2018 42
2019 43
2020 36
2021 35
2022 31
2023 31
2024 13

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423 results

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Page 1
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer.
Chen Y, Kim J, Yang S, Wang H, Wu CJ, Sugimoto H, LeBleu VS, Kalluri R. Chen Y, et al. Cancer Cell. 2021 Apr 12;39(4):548-565.e6. doi: 10.1016/j.ccell.2021.02.007. Epub 2021 Mar 4. Cancer Cell. 2021. PMID: 33667385 Free PMC article.
Stromal desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) involves significant accumulation of type I collagen (Col1). However, the precise molecular and mechanistic contribution of Col1 in PDAC progression remains unknown. ...Col1 deletion lea …
Stromal desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) involves significant accumulation of type I collagen (Col1). …
Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer.
Chen Y, Yang S, Tavormina J, Tampe D, Zeisberg M, Wang H, Mahadevan KK, Wu CJ, Sugimoto H, Chang CC, Jenq RR, McAndrews KM, Kalluri R. Chen Y, et al. Cancer Cell. 2022 Aug 8;40(8):818-834.e9. doi: 10.1016/j.ccell.2022.06.011. Epub 2022 Jul 21. Cancer Cell. 2022. PMID: 35868307 Free PMC article.
In contrast to normal type I collagen (Col1) heterotrimer (alpha1/alpha2/alpha1) produced by fibroblasts, pancreatic cancer cells specifically produce unique Col1 homotrimer (alpha1/alpha1/alpha1). ...This study identifies the functional impact of Col1 homotr …
In contrast to normal type I collagen (Col1) heterotrimer (alpha1/alpha2/alpha1) produced by fibroblasts, pancreatic cancer cells spe …
Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta.
Chen Y, Yang S, Lovisa S, Ambrose CG, McAndrews KM, Sugimoto H, Kalluri R. Chen Y, et al. Nat Commun. 2021 Dec 10;12(1):7199. doi: 10.1038/s41467-021-27563-3. Nat Commun. 2021. PMID: 34893625 Free PMC article.
Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of the total organic component of bone matrix. ...We generate transgenic mouse models to genetically delete Col1 in various cell lineages. Complete, whole-body Col1 …
Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of the total organic component of bone …
Chain alignment of collagen I deciphered using computationally designed heterotrimers.
Jalan AA, Sammon D, Hartgerink JD, Brear P, Stott K, Hamaia SW, Hunter EJ, Walker DR, Leitinger B, Farndale RW. Jalan AA, et al. Nat Chem Biol. 2020 Apr;16(4):423-429. doi: 10.1038/s41589-019-0435-y. Epub 2020 Jan 6. Nat Chem Biol. 2020. PMID: 31907373 Free PMC article.
Despite five decades of intensive research, there is no consensus on the position of chain B in COL1. Here, three triple-helical heterotrimers that each contain a putative von Willebrand factor (VWF) and discoidin domain receptor (DDR) recognition sequence from COL1 …
Despite five decades of intensive research, there is no consensus on the position of chain B in COL1. Here, three triple-helical hete …
LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis.
Wang Y, Ping Z, Gao H, Liu Z, Xv Q, Jiang X, Yu W. Wang Y, et al. Autophagy. 2024 May;20(5):1114-1133. doi: 10.1080/15548627.2023.2287930. Epub 2023 Nov 30. Autophagy. 2024. PMID: 38037248
The results showed that LYC could inhibit the AKT signaling pathway to activate mitophagy and reduce renal fibrosis.Abbreviation: AA: aristolochic acid; ACTA2/alpha-SMA: actin alpha 2, smooth muscle, aorta; ACTB: actin beta; AKT/protein kinase B: thymoma viral proto-oncogene; BAF …
The results showed that LYC could inhibit the AKT signaling pathway to activate mitophagy and reduce renal fibrosis.Abbreviation: AA: aristo …
Type I collagen decorated nanoporous network on titanium implant surface promotes osseointegration through mediating immunomodulation, angiogenesis, and osteogenesis.
Zhao Y, Bai L, Zhang Y, Yao R, Sun Y, Hang R, Chen X, Wang H, Yao X, Xiao Y, Hang R. Zhao Y, et al. Biomaterials. 2022 Sep;288:121684. doi: 10.1016/j.biomaterials.2022.121684. Epub 2022 Jul 20. Biomaterials. 2022. PMID: 35995624
To achieve efficient and long-term osseointegration, type I collagen (COL1) decorated nanoporous network was developed on titanium substrates via alkali treatment, polydopamine coating, and layer-by-layer (LBL) self-assembly. It was noted that the simple physisorbed COL …
To achieve efficient and long-term osseointegration, type I collagen (COL1) decorated nanoporous network was developed on titanium su …
Hydrogel-hydroxyapatite-monomeric collagen type-I scaffold with low-frequency electromagnetic field treatment enhances osteochondral repair in rabbits.
Yan J, Liu C, Tu C, Zhang R, Tang X, Li H, Wang H, Ma Y, Zhang Y, Wu H, Sheng G. Yan J, et al. Stem Cell Res Ther. 2021 Nov 13;12(1):572. doi: 10.1186/s13287-021-02638-6. Stem Cell Res Ther. 2021. PMID: 34774092 Free PMC article.
METHODS: In this study, a composite scaffold made of Hydroxyapatite-Collagen type-I (HAC) and PLGA-PEG-PLGA thermogel was produced to match the cartilage and subchondral layers in osteochondral defects, respectively. ...In vivo results further confirmed that …
METHODS: In this study, a composite scaffold made of Hydroxyapatite-Collagen type-I (HAC) and PLGA-PEG-PLGA thermogel w …
Extracellular Matrix in Heart Disease: Focus on Circulating Collagen Type I and III Derived Peptides as Biomarkers of Myocardial Fibrosis and Their Potential in the Prognosis of Heart Failure: A Concise Review.
Nikolov A, Popovski N. Nikolov A, et al. Metabolites. 2022 Mar 28;12(4):297. doi: 10.3390/metabo12040297. Metabolites. 2022. PMID: 35448484 Free PMC article. Review.
Accumulating evidence indicates that two major proteins are responsible for the structural coherence of bounding cardiomyocytes. These biomolecules are known as myocardial fibrillar collagen type I (COL1) and type III (COL3). In addition, fibronectin, …
Accumulating evidence indicates that two major proteins are responsible for the structural coherence of bounding cardiomyocytes. These biomo …
Both TGF-β1 and Smad4 regulate type I collagen expression in the muscle of grass carp, Ctenopharyngodon idella.
Xia Y, Yu E, Li Z, Zhang K, Tian J, Wang G, Xie J, Gong W. Xia Y, et al. Fish Physiol Biochem. 2021 Aug;47(4):907-917. doi: 10.1007/s10695-021-00941-w. Epub 2021 Apr 4. Fish Physiol Biochem. 2021. PMID: 33813689
To clarify this point, the effect of TGF-beta1 and Smad4 over-expression and RNAi knockdown on type I collagen (COL1-alpha1 and COL1-alpha2) expression were tested in vitro (zebrafish ZF4 cells) and in vivo (grass carp) along with the TGF-beta1/Smad4 co-expression a …
To clarify this point, the effect of TGF-beta1 and Smad4 over-expression and RNAi knockdown on type I collagen (COL1-alpha1 and CO …
423 results