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"Physiological Dysregulation" as Promising Measure of Robustness and Resilience in Aging Studies and New Indicator of Preclinical Disease.

Arbeev KG, Ukraintseva SV, Bagley O, Zhbannikov IY, Cohen AA, Kulminski AM, Yashin AI.

J Gerontol A Biol Sci Med Sci. 2018 Jun 22. doi: 10.1093/gerona/gly136. [Epub ahead of print]


Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship.

Brunet MA, Levesque SA, Hunting DJ, Cohen AA, Roucou X.

Genome Res. 2018 May;28(5):609-624. doi: 10.1101/gr.230938.117. Epub 2018 Apr 6.


Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, Witkowski JM, Franceschi C.

Front Immunol. 2018 Jan 10;8:1960. doi: 10.3389/fimmu.2017.01960. eCollection 2017. Review.


Co-existence of multiple trade-off currencies shapes evolutionary outcomes.

Cohen AA, Isaksson C, Salguero-Gómez R.

PLoS One. 2017 Dec 7;12(12):e0189124. doi: 10.1371/journal.pone.0189124. eCollection 2017.


Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?

Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A.

Am J Epidemiol. 2018 Jun 1;187(6):1220-1230. doi: 10.1093/aje/kwx346.


Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins.

Samandi S, Roy AV, Delcourt V, Lucier JF, Gagnon J, Beaudoin MC, Vanderperre B, Breton MA, Motard J, Jacques JF, Brunelle M, Gagnon-Arsenault I, Fournier I, Ouangraoua A, Hunting DJ, Cohen AA, Landry CR, Scott MS, Roucou X.

Elife. 2017 Oct 30;6. pii: e27860. doi: 10.7554/eLife.27860.


Mother's curse neutralizes natural selection against a human genetic disease over three centuries.

Milot E, Moreau C, Gagnon A, Cohen AA, Brais B, Labuda D.

Nat Ecol Evol. 2017 Sep;1(9):1400-1406. doi: 10.1038/s41559-017-0276-6. Epub 2017 Aug 21.


The mystery of life beyond menopause.

Cohen AA.

Nat Ecol Evol. 2017 Nov;1(11):1604-1605. doi: 10.1038/s41559-017-0356-7. No abstract available.


Men Sustain Higher Dysregulation Levels Than Women Without Becoming Frail.

Cohen AA, Legault V, Li Q, Fried LP, Ferrucci L.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):175-184. doi: 10.1093/gerona/glx146.


The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations.

Cohen AA, Legault V, Fuellen G, Fülöp T, Fried LP, Ferrucci L.

Exp Gerontol. 2018 Jul 1;107:11-17. doi: 10.1016/j.exger.2017.07.011. Epub 2017 Jul 16. Review.


Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging.

Cohen AA.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2680-2689. doi: 10.1016/j.bbadis.2017.05.028. Epub 2017 Jul 6. Review.


Interview with Alexander Cohen.

Cohen AA.

Future Cardiol. 2017 May;13(3):207-209. doi: 10.2217/fca-2017-0024. Epub 2017 Jun 1.


Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.

Wang H, Cohen AA, Galimidi RP, Gristick HB, Jensen GJ, Bjorkman PJ.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7151-E7158. Epub 2016 Oct 31.


Deep biomarkers of aging are population-dependent.

Cohen AA, Morissette-Thomas V, Ferrucci L, Fried LP.

Aging (Albany NY). 2016 Sep 8;8(9):2253-2255. doi: 10.18632/aging.101034. No abstract available.


Comparative effectiveness and safety of antipsychotic drugs in schizophrenia treatment: a real-world observational study.

Vanasse A, Blais L, Courteau J, Cohen AA, Roberge P, Larouche A, Grignon S, Fleury MJ, Lesage A, Demers MF, Roy MA, Carrier JD, Delorme A.

Acta Psychiatr Scand. 2016 Nov;134(5):374-384. doi: 10.1111/acps.12621. Epub 2016 Jul 12.


Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE.

Serme-Gbedo YK, Abdelouahab N, Pasquier JC, Cohen AA, Takser L.

Environ Health. 2016 Apr 12;15:49. doi: 10.1186/s12940-016-0134-z.


Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.

Arbeev KG, Cohen AA, Arbeeva LS, Milot E, Stallard E, Kulminski AM, Akushevich I, Ukraintseva SV, Christensen K, Yashin AI.

Front Public Health. 2016 Jan 25;4:3. doi: 10.3389/fpubh.2016.00003. eCollection 2016.


A New Cost-Effectiveness Modelling Approach In Chronic Heart Failure With Reduced Ejection Fraction.

McMurray JJ, Cowie MR, Cohen AA, Briggs A, de Pouvourville G, Taylor M, Hancock E, Trueman D, Mumby-Croft J, Haroun R, Deschaseaux C.

Value Health. 2015 Nov;18(7):A394. doi: 10.1016/j.jval.2015.09.887. Epub 2015 Oct 20. No abstract available.


Homeostatic dysregulation proceeds in parallel in multiple physiological systems.

Li Q, Wang S, Milot E, Bergeron P, Ferrucci L, Fried LP, Cohen AA.

Aging Cell. 2015 Dec;14(6):1103-12. doi: 10.1111/acel.12402. Epub 2015 Sep 29.


A theoretical model of the evolution of actuarial senescence under environmental stress.

Watson H, Cohen AA, Isaksson C.

Exp Gerontol. 2015 Nov;71:80-8. doi: 10.1016/j.exger.2015.08.009. Epub 2015 Aug 31.

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