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Nat Rev Endocrinol. 2014 May;10(5):258-60. doi: 10.1038/nrendo.2014.38. Epub 2014 Apr 1.

Diabetes. Cognitive decline and T2DM--a disconnect in the evidence?

Author information

1
Metabolic Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
2
Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.

Abstract

Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. Observational data suggest that hyperglycaemia, hypertension and dyslipidaemia might be involved in the causal pathway underlying this link, but data from the ACCORD MIND investigators challenge these findings. Why are the findings of observational and intervention studies so disconnected?

PMID:
24686200
DOI:
10.1038/nrendo.2014.38
[Indexed for MEDLINE]

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