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Semin Nephrol. 2015 Jul;35(4):304-10. doi: 10.1016/j.semnephrol.2015.06.002.

Cognitive Function in Patients With Chronic Kidney Disease: Challenges in Neuropsychological Assessments.

Author information

1
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
2
Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
3
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
4
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Behavioral Sciences, Semmelweis University in Budapest, Budapest, Hungary. Electronic address: marta.novak@uhn.on.ca.

Abstract

Cognitive dysfunction is a common symptom in patients with chronic kidney disease (CKD). In this review, we highlight the clinical relevance of cognitive impairment in patients with CKD. After a summary of the different pathophysiological components of this frequently overlooked clinical condition, we summarize and evaluate the available neurocognitive tests and reflect on their utility in everyday clinical practice. Finally, we identify future areas of research and allude to the fact that inclusion of cognitive function testing in routine clinical care of patients with CKD could be cost effective by reducing nonadherence to medication and improving quality of life, and even survival.

KEYWORDS:

Cognitive impairment; chronic kidney disease; cognitive dysfunction; dialysis; neuropsychological testing

[Indexed for MEDLINE]

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