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Subst Use Misuse. 2015 Jan;50(1):40-52. doi: 10.3109/10826084.2014.957771. Epub 2014 Oct 7.

Cognitive control network function in alcohol use disorder before and during treatment with lorazepam.

Author information

1
1Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.

Abstract

Individuals with alcohol use disorders (AUDs) have deficits in cognitive control, but how they change with treatment is unclear. Seven patients with AUD and anxiety from an open-label trial of disulfiram plus lorazepam performed a multisensory Stroop task during fMRI (both pre and post initiation of treatment), and were compared to nine healthy controls (HCs) (n = 16; Albuquerque, NM; years 2009-2012). Evoked BOLD signal and resting state functional connectivity were compared (HC vs. AUD; Scan 1 vs. Scan 2). AUD demonstrated hyperactivity and altered connectivity in the cognitive control network compared to HC, but treatment did not normalize function.

KEYWORDS:

Stroop; alcohol dependence; alcohol use disorder; benzodiazepine; cognitive control; connectivity; fMRI; lorazepam; treatment

PMID:
25290463
PMCID:
PMC4418428
DOI:
10.3109/10826084.2014.957771
[Indexed for MEDLINE]
Free PMC Article

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