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Items: 1 to 20 of 21


The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 nuclease-helicase at DNA double strand breaks.

Sorenson KS, Mahaney BL, Lees-Miller SP, Cobb JA.

J Biol Chem. 2017 Sep 1;292(35):14576-14586. doi: 10.1074/jbc.M117.796011. Epub 2017 Jul 5.


A decade of understanding spatio-temporal regulation of DNA repair by the nuclear architecture.

Saad H, Cobb JA.

Biochem Cell Biol. 2016 Oct;94(5):433-440. Epub 2016 Jul 20. Review.


Smc5/6 Is a Telomere-Associated Complex that Regulates Sir4 Binding and TPE.

Moradi-Fard S, Sarthi J, Tittel-Elmer M, Lalonde M, Cusanelli E, Chartrand P, Cobb JA.

PLoS Genet. 2016 Aug 26;12(8):e1006268. doi: 10.1371/journal.pgen.1006268. eCollection 2016 Aug.


Non-Smc element 5 (Nse5) of the Smc5/6 complex interacts with SUMO pathway components.

Bustard DE, Ball LG, Cobb JA.

Biol Open. 2016 Jun 15;5(6):777-85. doi: 10.1242/bio.018440.


PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.

Horigome C, Bustard DE, Marcomini I, Delgoshaie N, Tsai-Pflugfelder M, Cobb JA, Gasser SM.

Genes Dev. 2016 Apr 15;30(8):931-45. doi: 10.1101/gad.277665.116. Epub 2016 Apr 7.


The Mre11-Rad50-Xrs2 complex is required for yeast DNA postreplication repair.

Ball LG, Hanna MD, Lambrecht AD, Mitchell BA, Ziola B, Cobb JA, Xiao W.

PLoS One. 2014 Oct 24;9(10):e109292. doi: 10.1371/journal.pone.0109292. eCollection 2014.


The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining.

Mahaney BL, Lees-Miller SP, Cobb JA.

DNA Repair (Amst). 2014 Feb;14:9-16. doi: 10.1016/j.dnarep.2013.12.002. Epub 2013 Dec 24.


Cohesin association to replication sites depends on rad50 and promotes fork restart.

Tittel-Elmer M, Lengronne A, Davidson MB, Bacal J, François P, Hohl M, Petrini JHJ, Pasero P, Cobb JA.

Mol Cell. 2012 Oct 12;48(1):98-108. doi: 10.1016/j.molcel.2012.07.004. Epub 2012 Aug 9.


During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.

Bustard DE, Menolfi D, Jeppsson K, Ball LG, Dewey SC, Shirahige K, Sjögren C, Branzei D, Cobb JA.

J Biol Chem. 2012 Mar 30;287(14):11374-83. doi: 10.1074/jbc.M111.336263. Epub 2012 Feb 2.


DNA double strand breaks: not all foci are created equal.

Cobb JA, Lees-Miller SP.

Cell Cycle. 2010 Feb 1;9(3):442-3. Epub 2010 Feb 1. No abstract available.


The yeast Shu complex couples error-free post-replication repair to homologous recombination.

Ball LG, Zhang K, Cobb JA, Boone C, Xiao W.

Mol Microbiol. 2009 Jul;73(1):89-102. doi: 10.1111/j.1365-2958.2009.06748.x. Epub 2009 Jun 1.


The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress.

Tittel-Elmer M, Alabert C, Pasero P, Cobb JA.

EMBO J. 2009 Apr 22;28(8):1142-56. doi: 10.1038/emboj.2009.60. Epub 2009 Mar 12.


RecQ helicases: lessons from model organisms.

Cobb JA, Bjergbaek L.

Nucleic Acids Res. 2006;34(15):4106-14. Epub 2006 Aug 26. Review.


Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.

Cobb JA, Schleker T, Rojas V, Bjergbaek L, Tercero JA, Gasser SM.

Genes Dev. 2005 Dec 15;19(24):3055-69.


Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.

Bjergbaek L, Cobb JA, Tsai-Pflugfelder M, Gasser SM.

EMBO J. 2005 Jan 26;24(2):405-17. Epub 2004 Dec 23.


Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint response.

Cobb JA, Shimada K, Gasser SM.

Curr Opin Genet Dev. 2004 Jun;14(3):292-300. Review.


RecQ helicases: multiple roles in genome maintenance.

Khakhar RR, Cobb JA, Bjergbaek L, Hickson ID, Gasser SM.

Trends Cell Biol. 2003 Sep;13(9):493-501. Review.


DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.

Cobb JA, Bjergbaek L, Shimada K, Frei C, Gasser SM.

EMBO J. 2003 Aug 15;22(16):4325-36.


Phosphorylation of soybean nodulin 26 on serine 262 enhances water permeability and is regulated developmentally and by osmotic signals.

Guenther JF, Chanmanivone N, Galetovic MP, Wallace IS, Cobb JA, Roberts DM.

Plant Cell. 2003 Apr;15(4):981-91.


RecQ helicases and genome stability: lessons from model organisms and human disease.

Bjergbaek L, Cobb JA, Gasser SM.

Swiss Med Wkly. 2002 Aug 10;132(31-32):433-42.


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