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Nat Rev Cancer. 2014 Jun;14(6):395-405. doi: 10.1038/nrc3728.

Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions.

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Department of Pathology, VU University Medical Center, PO box 7057, 1007 Amsterdam, The Netherlands.


Infection of cervical epithelium with high-risk human papilloma virus (hrHPV) might result in productive or transforming cervical intraepithelial neoplasia (CIN) lesions, the morphology of which can overlap. In transforming CIN lesions, aberrations in host cell genes accumulate over time, which is necessary for the ultimate progression to cancer. On the basis of (epi)genetic changes, early and advanced transforming CIN lesions can be distinguished. This paves the way for new molecular tools for cervical screening, diagnosis and management of cervical cancer precursor lesions.

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