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FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. Clifford BL, et al. Cell Metab. 2021 Aug 3;33(8):1671-1684.e4. doi: 10.1016/j.cmet.2021.06.012. Epub 2021 Jul 15. Cell Metab. 2021. PMID: 34270928 Free PMC article.
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis.
Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Xiao X, et al. Among authors: clifford bl. Nat Metab. 2023 Jan;5(1):165-181. doi: 10.1038/s42255-022-00722-6. Epub 2023 Jan 16. Nat Metab. 2023. PMID: 36646756 Free PMC article.
RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels.
Clifford BL, Jarrett KE, Cheng J, Cheng A, Seldin M, Morand P, Lee R, Chen M, Baldan A, de Aguiar Vallim TQ, Tarling EJ. Clifford BL, et al. Circ Res. 2023 Mar 31;132(7):849-863. doi: 10.1161/CIRCRESAHA.122.321938. Epub 2023 Mar 6. Circ Res. 2023. PMID: 36876496 Free PMC article.
An integrative systems genetic analysis of mammalian lipid metabolism.
Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. Parker BL, et al. Among authors: clifford bl. Nature. 2019 Mar;567(7747):187-193. doi: 10.1038/s41586-019-0984-y. Epub 2019 Feb 27. Nature. 2019. PMID: 30814737 Free PMC article.
MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice.
Cheng J, Cheng A, Clifford BL, Wu X, Hedin U, Maegdefessel L, Pamir N, Sallam T, Tarling EJ, de Aguiar Vallim TQ. Cheng J, et al. Among authors: clifford bl. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):412-425. doi: 10.1161/ATVBAHA.119.313633. Epub 2019 Dec 19. Arterioscler Thromb Vasc Biol. 2020. PMID: 31852219 Free PMC article.