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Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis.
Mulvihill EE, Burke AC, Huff MW. Mulvihill EE, et al. Annu Rev Nutr. 2016 Jul 17;36:275-99. doi: 10.1146/annurev-nutr-071715-050718. Epub 2016 May 4. Annu Rev Nutr. 2016. PMID: 27146015 Review.
This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid metabolism, other metabolic parameters related to the metabolic syndrome, and atherosclerosis. ...Citrus flavonoids b …
This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid metabolism, …
Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway.
Zhao H, Liu M, Liu H, Suo R, Lu C. Zhao H, et al. Biosci Rep. 2020 Mar 27;40(3):BSR20193431. doi: 10.1042/BSR20193431. Biosci Rep. 2020. PMID: 32091090 Free PMC article.
Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial-mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including …
Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apo …
Naringenin and atherosclerosis: a review of literature.
Orhan IE, Nabavi SF, Daglia M, Tenore GC, Mansouri K, Nabavi SM. Orhan IE, et al. Curr Pharm Biotechnol. 2015;16(3):245-51. doi: 10.2174/1389201015666141202110216. Curr Pharm Biotechnol. 2015. PMID: 25483717 Review.
Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein (LD) cholesterol in macrophages of arterial walls. ...Naringenin is a well known flavonoid belonging to the chemical class of flavanones. It is especially abund …
Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein (LD) cholesterol in macroph …
Efficacy of nobiletin in improving hypercholesterolemia and nonalcoholic fatty liver disease in high-cholesterol diet-fed mice.
Kim YJ, Yoon DS, Jung UJ. Kim YJ, et al. Nutr Res Pract. 2021 Aug;15(4):431-443. doi: 10.4162/nrp.2021.15.4.431. Epub 2021 Mar 11. Nutr Res Pract. 2021. PMID: 34349877 Free PMC article.
BACKGROUND/OBJECTIVES: Nobiletin (NOB), a citrus flavonoid, is reported to have beneficial effects on cardiovascular and metabolic health. ...Dietary NOB supplementation may protect against hypercholesterolemia and NAFLD via regulation of hepatic lipid …
BACKGROUND/OBJECTIVES: Nobiletin (NOB), a citrus flavonoid, is reported to have beneficial effects on cardiovascular and me …
Naringin Alleviates Atherosclerosis in ApoE(-/-) Mice by Regulating Cholesterol Metabolism Involved in Gut Microbiota Remodeling.
Wang F, Zhao C, Tian G, Wei X, Ma Z, Cui J, Wei R, Bao Y, Kong W, Zheng J. Wang F, et al. J Agric Food Chem. 2020 Nov 11;68(45):12651-12660. doi: 10.1021/acs.jafc.0c05800. Epub 2020 Oct 27. J Agric Food Chem. 2020. PMID: 33107729
Naringin, a major flavonoid in citrus, has potential for preventing atherosclerosis. ...In addition, naringin facilitated reverse cholesterol transport by downregulating PCSK9/IDOL. The results provide insight into the atherosclerosis-alleviation mecha …
Naringin, a major flavonoid in citrus, has potential for preventing atherosclerosis. ...In addition, naringin facilitat …
Role of hesperetin in LDL-receptor expression in hepatoma HepG2 cells.
Bawazeer NA, Choudhry H, Zamzami MA, Abdulaal WH, Middleton B, Moselhy SS. Bawazeer NA, et al. BMC Complement Altern Med. 2016 Jun 27;16:182. doi: 10.1186/s12906-016-1165-2. BMC Complement Altern Med. 2016. PMID: 27349523 Free PMC article.
BACKGROUND: High plasma concentration of low-density lipoprotein cholesterol (LDL-c) plays a significant role in the incidence of atherosclerosis and coronary heart diseases. The aim of this study was to investigate the mechanism by which the citrus flavon …
BACKGROUND: High plasma concentration of low-density lipoprotein cholesterol (LDL-c) plays a significant role in the incidence of …
POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE.
Bawazeer NA, Choudary H, Zamzami MA, Abdulaal WH, Zeyadi M, ALbukhari A, Middleton B, Moselhy SS. Bawazeer NA, et al. Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):278-287. doi: 10.21010/ajtcam.v14i1.30. eCollection 2017. Afr J Tradit Complement Altern Med. 2016. PMID: 28480406 Free PMC article.
BACKGROUND: High plasma concentration of low-density lipoprotein cholesterol (LDL-c) plays a significant role in the incidence of atherosclerosis and coronary heart diseases (CHD). MATERIALS AND METHODS: The purpose of this study was to investigate the mechanism by …
BACKGROUND: High plasma concentration of low-density lipoprotein cholesterol (LDL-c) plays a significant role in the incidence of …
Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.
Iio A, Ohguchi K, Iinuma M, Nozawa Y, Ito M. Iio A, et al. J Nat Prod. 2012 Apr 27;75(4):563-6. doi: 10.1021/np200696r. Epub 2012 Mar 19. J Nat Prod. 2012. PMID: 22429094
ABCA1, a member of the ATP-binding cassette transporter family, regulates high-density lipoprotein (HDL) metabolism and cholesterol transport. ...Firefly luciferase reporter assays were developed for human ABCA1 promoters and LXR enhancers, and an in-house ph …
ABCA1, a member of the ATP-binding cassette transporter family, regulates high-density lipoprotein (HDL) metabolism and …
Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells.
Eguchi A, Murakami A, Li S, Ho CT, Ohigashi H. Eguchi A, et al. Biofactors. 2007;31(2):107-16. doi: 10.1002/biof.5520310201. Biofactors. 2007. PMID: 18806314
Unregulated uptake of oxidized low-density lipoproteins (ox-LDL) via macrophage scavenger receptors (SRs) is a key event in atherosclerosis. We previously reported that nobiletin (NOB), a citrus polymethoxylated flavone, markedly reduced 12-O-tetradecanoylpho …
Unregulated uptake of oxidized low-density lipoproteins (ox-LDL) via macrophage scavenger receptors (SRs) is a key event in athero …
Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Koga M, Kanaoka Y, Inada K, Omine S, Kataoka Y, Yamauchi A. Koga M, et al. J Pharmacol Sci. 2020 Jun;143(2):106-111. doi: 10.1016/j.jphs.2020.01.012. Epub 2020 Feb 28. J Pharmacol Sci. 2020. PMID: 32173266 Free article.
This adverse effect is likely due to enhanced net uptake of oxidized low-density lipoprotein (oxLDL) in macrophages as a result of increased scavenger receptors and decreased cholesterol efflux transporters. ...The aim of this study was to examine the effect of hesperidin, …
This adverse effect is likely due to enhanced net uptake of oxidized low-density lipoprotein (oxLDL) in macrophages as a result of in …
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