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Sci Rep. 2018 Oct 11;8(1):15115. doi: 10.1038/s41598-018-33491-y.

Circulating miR-1254 predicts ventricular remodeling in patients with ST-Segment-Elevation Myocardial Infarction: A cardiovascular magnetic resonance study.

Author information

1
Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.
2
Institute of Biomedical Research of Barcelona (IIBB) - Spanish National Research Council (CSIC), Barcelona, Spain.
3
CIBERCV, Institute of Health Carlos III, Madrid, Spain.
4
Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
5
Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.
6
Department of Medicine, CIBERCV Autonomous University of Barcelona, Badalona, Spain.
7
Cardiology Department, Hospital Clínico Universitario, INCLIVA, Departamento de Medicina, CIBERCV Universitat València, València, Spain.
8
Heart Failure and Cardiac Regeneration (ICREC) Research Program, Health Science Research Institute Germans Trias i Pujol (IGTP), Badalona, Spain.
9
Universitat Politècnica de València, València, Spain.
10
Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany. thum.thomas@mh-hannover.de.
11
REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany. thum.thomas@mh-hannover.de.
12
Imperial College London, National Heart and Lung Institute, London, UK. thum.thomas@mh-hannover.de.
13
Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain. abayesgenis@gmail.com.
14
Department of Medicine, CIBERCV Autonomous University of Barcelona, Badalona, Spain. abayesgenis@gmail.com.

Abstract

Reliable noninvasive prognostic biomarkers for left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) are needed. This study aimed to evaluate a panel of circulating microRNAs (miRNAs) as biomarkers of LV remodeling using cardiovascular magnetic resonance (CMR). We prospectively evaluated patients with a first STEMI treated with primary percutaneous coronary intervention who underwent CMR imaging at 1 week and 6 months after STEMI (n = 70). miRNAs were measured using PCR-based technologies in plasma samples collected at admission. The associations between miRNAs and LV diastolic and systolic volumes, and ejection fraction at 6-months were estimated in adjusted models. Median age was 60 years, 71.4% were male. miR-1254 was significantly associated in univariate analyses. Patients in the highest tertile of miR-1254 exhibited lower values of LVEDVI and LVESVI and higher values of LVEF at 1 week. After comprehensive multivariate adjustment including clinical, CMR variables, hs-troponin-T and NT-proBNP, miRNA-1254 was associated with decreasing LVESVI (P = 0.006), and borderline negative associated with LVEDVI (P = 0.063) at 6-months. miR-1254 also exhibited a significant positive association with increasing LVEF during follow-up (P < 0.001). Plasma miRNA-1254 predicted changes in LV volumes and LVEF at 6 months after STEMI. The value of miR-1254 to inform tailored treatment selection and monitor ongoing efficacy deserves further investigation.

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