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J Bone Miner Res. 2013 May;28(5):992-6. doi: 10.1002/jbmr.1838.

Cinacalcet as adjunctive therapy for hereditary 1,25-dihydroxyvitamin D-resistant rickets.

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Section of Nephrology, Bone and Mineral Disorder Clinic, Children's Mercy Hospitals and Clinics, University of Missouri at Kansas City, Kansas City, MO 64108, USA.


Secondary hyperparathyroidism from inadequate calcium absorption in the gut, is the underlying pathophysiology for rachitic changes in hereditary vitamin D-resistant rickets (HVDRR). We describe a novel use of Cinacalcet to treat a child with HVDRR in whom conventional modes of therapy had to be discontinued. Cinacalcet therapy with high-dose oral calcium effectively normalized the metabolic abnormalities and bone condition. The relative ease of administration of the calcimimetic as a once- or twice-daily oral preparation, compared with traditional intravenous calcium administration, should encourage its move to the frontline of treatment of the disorder.

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