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Page 1
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, Erreni M, Markicevic M, Starvaggi-Cucuzza C, Otero K, Piccio L, Cignarella F, Perrucci F, Tamborini M, Genua M, Rajendran L, Menna E, Vetrano S, Fahnestock M, Paolicelli RC, Matteoli M. Filipello F, et al. Among authors: cignarella f. Immunity. 2018 May 15;48(5):979-991.e8. doi: 10.1016/j.immuni.2018.04.016. Epub 2018 May 8. Immunity. 2018. PMID: 29752066 Free article.
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, Manis M, Ibrahim A, Deng L, Benitez BA, Cruchaga C, Licastro D, Mihindukulasuriya K, Harari O, Buckland M, Holtzman DM, Rosenthal A, Schwabe T, Tassi I, Piccio L. Cignarella F, et al. Acta Neuropathol. 2020 Oct;140(4):513-534. doi: 10.1007/s00401-020-02193-z. Epub 2020 Aug 9. Acta Neuropathol. 2020. PMID: 32772264 Free PMC article.
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C. Deming Y, et al. Among authors: cignarella f. Sci Transl Med. 2019 Aug 14;11(505):eaau2291. doi: 10.1126/scitranslmed.aau2291. Sci Transl Med. 2019. PMID: 31413141 Free PMC article.
Cross-talk between B cells, microglia and macrophages, and implications to central nervous system compartmentalized inflammation and progressive multiple sclerosis.
Touil H, Li R, Zuroff L, Moore CS, Healy L, Cignarella F, Piccio L, Ludwin S, Prat A, Gommerman J, Bennett FC, Jacobs D, Benjamins JA, Lisak RP, Antel JP, Bar-Or A. Touil H, et al. Among authors: cignarella f. EBioMedicine. 2023 Oct;96:104789. doi: 10.1016/j.ebiom.2023.104789. Epub 2023 Sep 11. EBioMedicine. 2023. PMID: 37703640 Free PMC article.
A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity.
Giagulli C, Caccuri F, Cignarella F, Lougaris V, Martorelli D, Bugatti A, Rusnati M, Dolcetti R, Vitali M, Plebani A, Fiorentini S, Caruso A. Giagulli C, et al. Among authors: cignarella f. AIDS. 2014 Oct 23;28(16):2355-64. doi: 10.1097/QAD.0000000000000423. AIDS. 2014. PMID: 25121556
Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis.
Cantoni C, Cignarella F, Ghezzi L, Mikesell B, Bollman B, Berrien-Elliott MM, Ireland AR, Fehniger TA, Wu GF, Piccio L. Cantoni C, et al. Among authors: cignarella f. Acta Neuropathol. 2017 Jan;133(1):61-77. doi: 10.1007/s00401-016-1621-6. Epub 2016 Oct 4. Acta Neuropathol. 2017. PMID: 27704281 Free PMC article.