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Int J Mol Sci. 2018 Jul 14;19(7). pii: E2051. doi: 10.3390/ijms19072051.

Vitamin D and Uterine Fibroids-Review of the Literature and Novel Concepts.

Author information

1
Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland. michal.ciebiera@gmail.com.
2
Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy with Division of Laboratory Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland. mdwlodarczyk@gmail.com.
3
Center for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland. mdwlodarczyk@gmail.com.
4
Students' Scientific Association at the Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland. mciebiera93@gmail.com.
5
Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland. kornelia3@poczta.onet.pl.
6
Department of Obstetrics and Gynecological Nursing, Faculty of Health Sciences, Medical University of Gdansk, 80-210 Gdansk, Poland. luka@gumed.edu.pl.
7
INVICTA Fertility and Reproductive Center, 80-172 Gdansk, Poland. luka@gumed.edu.pl.
8
Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland. grzegorz.jakiel1@o2.pl.

Abstract

This article provides a detailed review of current knowledge on the role of vitamin D and its receptor in the biology and management of uterine fibroids (UFs). Authors present ideas for future steps in this area. A literature search was conducted in PubMed using the following key words: "uterine fibroid" and "vitamin D". The results of the available studies, published in English from January 2002 up to April 2018, have been discussed. Vitamin D is a group of steroid compounds with a powerful impact on many parts of the human body. This vitamin is believed to regulate cell proliferation and differentiation, inhibit angiogenesis, and stimulate apoptosis. Nowadays, hypovitaminosis D is believed to be a major risk factor in the development of UFs. In many studies vitamin D appears to be a powerful factor against UFs, resulting in inhibition of tumor cell division and a significant reduction in its size, however, the exact role of this compound and its receptor in the pathophysiology of UFs is not fully understood. According to available studies, vitamin D and its analogs seem to be promising, effective, and low-cost compounds in the management of UFs and their clinical symptoms, and the anti-tumor activities of vitamin D play an important role in UF biology. The synergy between vitamin D and selected anti-UF drugs is a very interesting issue which requires further research. Further studies about the biological effect of vitamin D on UF biology are essential. Vitamin D preparations (alone or as a co-drugs) could become new tools in the fight with UFs, with the additional beneficial pleiotropic effect.

KEYWORDS:

leiomyoma; uterine fibroid; vitamin D; vitamin D analogs; vitamin D receptor

PMID:
30011902
PMCID:
PMC6073230
DOI:
10.3390/ijms19072051
[Indexed for MEDLINE]
Free PMC Article

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