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Cell. 2018 Sep 20;175(1):38-40. doi: 10.1016/j.cell.2018.08.068.

Chromatin Domains Go on Repeat in Disease.

Author information

1
Gladstone Institutes, San Francisco, CA 94158, USA; Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: benoit.bruneau@gladstone.ucsf.edu.
2
Gladstone Institutes, San Francisco, CA 94158, USA; Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: elphege.nora@gladstone.ucsf.edu.

Abstract

TAD boundaries are insulators of genomic neighborhoods. In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulation. The findings have important implications for TAD function and mechanisms underlying diseases such as fragile X syndrome and Huntington's disease.

PMID:
30241613
DOI:
10.1016/j.cell.2018.08.068

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