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Items: 17


The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis.

Thibodeaux CJ, Liu HW.

Arch Biochem Biophys. 2017 Oct 15;632:47-58. doi: 10.1016/ Epub 2017 May 31. Review.


Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.

Thibodeaux CJ, Wagoner J, Yu Y, van der Donk WA.

J Am Chem Soc. 2016 May 25;138(20):6436-44. doi: 10.1021/jacs.6b00163. Epub 2016 May 10.


Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes.

Ju KS, Gao J, Doroghazi JR, Wang KK, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, van der Donk WA, Metcalf WW.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12175-80. doi: 10.1073/pnas.1500873112. Epub 2015 Aug 31.


A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2.

Thibodeaux CJ, Ha T, van der Donk WA.

J Am Chem Soc. 2014 Dec 17;136(50):17513-29. doi: 10.1021/ja5089452. Epub 2014 Dec 4.


Converging on a mechanism for choline degradation.

Thibodeaux CJ, van der Donk WA.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21184-5. doi: 10.1073/pnas.1219534110. Epub 2012 Dec 14. No abstract available.


Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase.

Sun HG, Ruszczycky MW, Chang WC, Thibodeaux CJ, Liu HW.

J Biol Chem. 2012 Feb 10;287(7):4602-8. doi: 10.1074/jbc.M111.312538. Epub 2011 Dec 20.


Stereochemical studies of the type II isopentenyl diphosphate-dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation.

Calveras J, Thibodeaux CJ, Mansoorabadi SO, Liu HW.

Chembiochem. 2012 Jan 2;13(1):42-6. doi: 10.1002/cbic.201100694. Epub 2011 Dec 1. No abstract available.


Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.

Thibodeaux CJ, Chang WC, Liu HW.

Chem Rev. 2012 Mar 14;112(3):1681-709. doi: 10.1021/cr200073d. Epub 2011 Oct 21. Review. No abstract available.


Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.

Thibodeaux CJ, Liu HW.

Biochemistry. 2011 Mar 22;50(11):1950-62. doi: 10.1021/bi101927s. Epub 2011 Feb 3.


Enzymatic synthesis of TDP-deoxysugars.

White-Phillip J, Thibodeaux CJ, Liu HW.

Methods Enzymol. 2009;459:521-44. doi: 10.1016/S0076-6879(09)04621-7.


Natural-product sugar biosynthesis and enzymatic glycodiversification.

Thibodeaux CJ, Melançon CE 3rd, Liu HW.

Angew Chem Int Ed Engl. 2008;47(51):9814-59. doi: 10.1002/anie.200801204. Review.


Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus.

Thibodeaux CJ, Mansoorabadi SO, Kittleman W, Chang WC, Liu HW.

Biochemistry. 2008 Feb 26;47(8):2547-58. doi: 10.1021/bi701467g. Epub 2008 Jan 30.


Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus.

Kittleman W, Thibodeaux CJ, Liu YN, Zhang H, Liu HW.

Biochemistry. 2007 Jul 17;46(28):8401-13. Epub 2007 Jun 22.


The diverse roles of flavin coenzymes--nature's most versatile thespians.

Mansoorabadi SO, Thibodeaux CJ, Liu HW.

J Org Chem. 2007 Aug 17;72(17):6329-42. Epub 2007 Jun 20. Review.


Unusual sugar biosynthesis and natural product glycodiversification.

Thibodeaux CJ, Melançon CE, Liu HW.

Nature. 2007 Apr 26;446(7139):1008-16. Review.


Glyco-stripping and glyco-swapping.

Melançon CE 3rd, Thibodeaux CJ, Liu HW.

ACS Chem Biol. 2006 Sep 19;1(8):499-504.


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