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Items: 1 to 20 of 189


Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC)-Mediated Macrocyclization of Peptides: Impact on Conformation and Biological Activity.

Testa C, Papini AM, Chorev M, Rovero P.

Curr Top Med Chem. 2018;18(7):591-610. doi: 10.2174/1568026618666180518095755. Review.


A Data-Driven Decision-Support Tool for Population Health Policies.

Chorev M, Shpigelman L, Bak P, Yaeli A, Michael E, Goldschmidt Y.

Stud Health Technol Inform. 2017;245:332-336.


Identification of introns harboring functional sequence elements through positional conservation.

Chorev M, Joseph Bekker A, Goldberger J, Carmel L.

Sci Rep. 2017 Jun 23;7(1):4201. doi: 10.1038/s41598-017-04476-0.


Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response.

Yefidoff-Freedman R, Fan J, Yan L, Zhang Q, Dos Santos GRR, Rana S, Contreras JI, Sahoo R, Wan D, Young J, Dias Teixeira KL, Morisseau C, Halperin J, Hammock B, Natarajan A, Wang P, Chorev M, Aktas BH.

J Med Chem. 2017 Jul 13;60(13):5392-5406. doi: 10.1021/acs.jmedchem.7b00059. Epub 2017 Jun 19.


Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance.

Ghosh P, Luque-Fernandez MA, Vaidya A, Ma D, Sahoo R, Chorev M, Zera C, McElrath TF, Williams MA, Seely EW, Halperin JA.

Diabetes Care. 2017 Jul;40(7):981-984. doi: 10.2337/dc16-2598. Epub 2017 Apr 27.


Epidemiological Models Lacking Process Noise Can Be Overconfident.

Shpigelman L, Chorev M, Waks Z, Goldschmidt Y, Michael E.

Stud Health Technol Inform. 2017;235:136-140.


LEMONS - A Tool for the Identification of Splice Junctions in Transcriptomes of Organisms Lacking Reference Genomes.

Levin L, Bar-Yaacov D, Bouskila A, Chorev M, Carmel L, Mishmar D.

PLoS One. 2015 Nov 25;10(11):e0143329. doi: 10.1371/journal.pone.0143329. eCollection 2015.


JuncDB: an exon-exon junction database.

Chorev M, Guy L, Carmel L.

Nucleic Acids Res. 2016 Jan 4;44(D1):D101-9. doi: 10.1093/nar/gkv1142. Epub 2015 Oct 30.


Role of complement and complement regulatory proteins in the complications of diabetes.

Ghosh P, Sahoo R, Vaidya A, Chorev M, Halperin JA.

Endocr Rev. 2015 Jun;36(3):272-88. doi: 10.1210/er.2014-1099. Epub 2015 Apr 10. Review.


1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.

Testa C, Scrima M, Grimaldi M, D'Ursi AM, Dirain ML, Lubin-Germain N, Singh A, Haskell-Luevano C, Chorev M, Rovero P, Papini AM.

J Med Chem. 2014 Nov 26;57(22):9424-34. doi: 10.1021/jm501027w. Epub 2014 Nov 13.


Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.

Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95. doi: 10.1073/pnas.1410250111. Epub 2014 Jul 21.


Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction.

Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M.

J Med Chem. 2014 Jun 26;57(12):5094-111. doi: 10.1021/jm401733v. Epub 2014 Jun 4.


Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M.

Eur J Med Chem. 2014 Apr 22;77:361-77. doi: 10.1016/j.ejmech.2014.03.034. Epub 2014 Mar 13.


Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans.

Ghosh P, Vaidya A, Sahoo R, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA.

J Clin Endocrinol Metab. 2014 Jun;99(6):E999-E1006. doi: 10.1210/jc.2013-4232. Epub 2014 Mar 14.


3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.

Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M.

Chembiochem. 2014 Mar 3;15(4):595-611. doi: 10.1002/cbic.201300723. Epub 2014 Jan 23.


Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH.

J Med Chem. 2013 Dec 12;56(23):9457-70. doi: 10.1021/jm400793v. Epub 2013 Nov 27.


Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Denoyelle S, Chen T, Yang H, Chen L, Zhang Y, Halperin JA, Aktas BH, Chorev M.

Eur J Med Chem. 2013 Nov;69:537-53. doi: 10.1016/j.ejmech.2013.08.030. Epub 2013 Sep 17.


Dual activators of protein kinase R (PKR) and protein kinase R-like kinase PERK identify common and divergent catalytic targets.

Bai H, Chen T, Ming J, Sun H, Cao P, Fusco DN, Chung RT, Chorev M, Jin Q, Aktas BH.

Chembiochem. 2013 Jul 8;14(10):1255-62. doi: 10.1002/cbic.201300177. Epub 2013 Jun 19.


A specific and sensitive assay for blood levels of glycated CD59: a novel biomarker for diabetes.

Ghosh P, Sahoo R, Vaidya A, Cantel S, Kavishwar A, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA.

Am J Hematol. 2013 Aug;88(8):670-6. doi: 10.1002/ajh.23478. Epub 2013 Jun 20.

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