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Items: 1 to 20 of 27

1.

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium , Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC.

Brain. 2018 Jun 26. doi: 10.1093/brain/awy159. [Epub ahead of print]

2.

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease.

Voytyuk I, De Strooper B, Chávez-Gutiérrez L.

Biol Psychiatry. 2018 Feb 15;83(4):320-327. doi: 10.1016/j.biopsych.2017.08.001. Epub 2017 Aug 10. Review.

PMID:
28918941
3.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L.

Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004.

4.

Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.

Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B.

EMBO Mol Med. 2017 Aug;9(8):1088-1099. doi: 10.15252/emmm.201707561.

5.

Identification and characterization of Nanobodies targeting the EphA4 receptor.

Schoonaert L, Rué L, Roucourt B, Timmers M, Little S, Chávez-Gutiérrez L, Dewilde M, Joyce P, Curnock A, Weber P, Haustraete J, Hassanzadeh-Ghassabeh G, De Strooper B, Van Den Bosch L, Van Damme P, Lemmens R, Robberecht W.

J Biol Chem. 2017 Jul 7;292(27):11452-11465. doi: 10.1074/jbc.M116.774141. Epub 2017 May 19.

6.

Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds.

Le Guennec K, Veugelen S, Quenez O, Szaruga M, Rousseau S, Nicolas G, Wallon D, Fluchere F, Frébourg T, De Strooper B, Campion D, Chávez-Gutiérrez L, Rovelet-Lecrux A.

Neurobiol Dis. 2017 Aug;104:97-103. doi: 10.1016/j.nbd.2017.04.020. Epub 2017 Apr 28.

PMID:
28461250
7.

Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins.

Veugelen S, Dewilde M, De Strooper B, Chávez-Gutiérrez L.

Methods Enzymol. 2017;584:59-97. doi: 10.1016/bs.mie.2016.10.029. Epub 2016 Dec 12. Review.

PMID:
28065273
8.

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Ryan NS, Nicholas JM, Weston PSJ, Liang Y, Lashley T, Guerreiro R, Adamson G, Kenny J, Beck J, Chavez-Gutierrez L, de Strooper B, Revesz T, Holton J, Mead S, Rossor MN, Fox NC.

Lancet Neurol. 2016 Dec;15(13):1326-1335. doi: 10.1016/S1474-4422(16)30193-4. Epub 2016 Oct 21.

9.

Probing γ-secretase-substrate interactions at the single amino acid residue level.

Chávez-Gutiérrez L, De Strooper B.

EMBO J. 2016 Aug 1;35(15):1597-9. doi: 10.15252/embj.201694978. Epub 2016 Jul 1. No abstract available.

10.

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L, De Strooper B.

Neuron. 2016 Apr 20;90(2):410-6. doi: 10.1016/j.neuron.2016.03.010.

11.

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.

Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L.

J Exp Med. 2015 Nov 16;212(12):2003-13. doi: 10.1084/jem.20150892. Epub 2015 Oct 19.

12.

Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease.

Ryan NS, Biessels GJ, Kim L, Nicholas JM, Barber PA, Walsh P, Gami P, Morris HR, Bastos-Leite AJ, Schott JM, Beck J, Mead S, Chavez-Gutierrez L, de Strooper B, Rossor MN, Revesz T, Lashley T, Fox NC.

Neurobiol Aging. 2015 Dec;36(12):3140-3151. doi: 10.1016/j.neurobiolaging.2015.08.026. Epub 2015 Sep 4.

PMID:
26410308
13.

The dynamic conformational landscape of gamma-secretase.

Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L.

J Cell Sci. 2015 Feb 1;128(3):589-98.

14.

Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

De Strooper B, Chávez Gutiérrez L.

Annu Rev Pharmacol Toxicol. 2015;55:419-37. doi: 10.1146/annurev-pharmtox-010814-124309. Epub 2014 Oct 1. Review.

PMID:
25292430
15.

Signature amyloid β profiles are produced by different γ-secretase complexes.

Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B.

J Biol Chem. 2014 Feb 14;289(7):4346-55. doi: 10.1074/jbc.M113.530907. Epub 2013 Dec 13.

16.

Dissecting γ-secretase function.

Chávez-Gutiérrez L.

J Neurochem. 2013 Apr;125(1):1-3. doi: 10.1111/jnc.12077. No abstract available.

17.

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.

Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P.

Neuron. 2012 Sep 20;75(6):1008-21. doi: 10.1016/j.neuron.2012.08.022.

18.

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B.

EMBO J. 2012 May 16;31(10):2261-74. doi: 10.1038/emboj.2012.79. Epub 2012 Apr 13.

19.

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B.

EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2.

20.

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.

Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B.

J Biol Chem. 2011 Apr 8;286(14):12271-82. doi: 10.1074/jbc.M110.216978. Epub 2011 Feb 4.

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