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J Crit Care. 2018 Jun;45:90-94. doi: 10.1016/j.jcrc.2018.01.003. Epub 2018 Jan 7.

Characteristics, incidence, and outcome of patients admitted to the intensive care unit with myasthenia gravis.

Author information

1
Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, Australia.
2
Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Alfred Hospital, Commercial Rd, Melbourne, Australia.
3
Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand; Medical Research Institute of New Zealand, Wellington, New Zealand.
4
Medical Research Institute of New Zealand, Wellington, New Zealand; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.
5
Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation, Melbourne, Australia.
6
Department of Intensive Care, Austin Hospital, Heidelberg, Melbourne, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Alfred Hospital, Commercial Rd, Melbourne, Australia. Electronic address: rinaldo.bellomo@austin.org.au.

Abstract

BACKGROUND:

There are limited data on the characteristics, incidence, and mortality of patients with myasthenia gravis (MG) admitted to the ICU.

AIMS:

To study the epidemiology, characteristics and outcome of patients with MG in Australian and New Zealand (ANZ) ICUs over a decade.

METHODS:

We performed a retrospective observational, cross sectional study of data from the Australian and New Zealand Intensive Care Society (ANZICS) Adult Patient Database (APD). We collected data on all adult patients admitted with a primary diagnosis of MG to 159 Australian and 19 New Zealand ICUs between January 1, 2005 and December 31, 2015.We extracted detailed relevant data and performed statistical assessment.

RESULTS:

We identified 245 patients admitted to ICU with the primary diagnosis of MG, with an incidence increasing from 1 to 2.5 per thousand ICU admissions (P<0.0001) and from 1 to 2.2 per million people (P=0.02). Mean age was 60years with more patients being female (53.7% vs 47.3%) and 91 (37.1%) patients received mechanical ventilation. Hospital mortality occurred in 13 (5.3%) patients with a mortality rate lower than in other ICU patients.

CONCLUSIONS:

In ANZ, the ICU and population incidence of MG has increased over the last decade. However, its mortality rate was low.

KEYWORDS:

Australia and New Zealand; Characteristics; Critical care outcome; Mortality; Myasthenia Gravis

PMID:
29413729
DOI:
10.1016/j.jcrc.2018.01.003
[Indexed for MEDLINE]

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