Chappell MD[Author] - Search Results

Year	Number of Results
2000	4
2001	3
2002	2
2016	2
2024	0

1

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.

Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C, Carpintero M, Diego JE, Barberis M, Garcia-Cerrada S, Soriano JF, Antonysamy S, Atwell S, MacEwan I, Condon B, Sougias C, Wang J, Zhang A, Conners K, Groshong C, Wasserman SR, Koss JW, Witkin JM, Li X, Overshiner C, Wafford KA, Seidel W, Wang XS, Heinz BA, Swanson S, Catlow JT, Bedwell DW, Monn JA, Mitch CH, Ornstein PL. Chappell MD, et al. J Med Chem. 2016 Dec 22;59(24):10974-10993. doi: 10.1021/acs.jmedchem.6b01119. Epub 2016 Dec 6. J Med Chem. 2016. PMID: 28002967

2

Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.

Dressman BA, Tromiczak EG, Chappell MD, Tripp AE, Quimby SJ, Vetman T, Fivush AM, Matt J, Jaramillo C, Li R, Khilevich A, Blanco MJ, Smith SC, Carpintero M, de Diego JE, Barberis M, García-Cerrada S, Soriano JF, Schkeryantz JM, Witkin JM, Wafford KA, Seidel W, Britton T, Overshiner CD, Li X, Wang XS, Heinz BA, Catlow JT, Swanson S, Bedwell D, Ornstein PL, Mitch CH. Dressman BA, et al. Among authors: chappell md. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5663-5668. doi: 10.1016/j.bmcl.2016.10.067. Epub 2016 Oct 25. Bioorg Med Chem Lett. 2016. PMID: 27836401

3

Design and synthesis of conformationally constrained glycosylated amino acids.

Koviach JL, Chappell MD, Halcomb RL. Koviach JL, et al. Among authors: chappell md. J Org Chem. 2001 Apr 6;66(7):2318-26. doi: 10.1021/jo001512z. J Org Chem. 2001. PMID: 11281772

4

Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.

Biswas K, Lin H, Njardarson JT, Chappell MD, Chou TC, Guan Y, Tong WP, He L, Horwitz SB, Danishefsky SJ. Biswas K, et al. Among authors: chappell md. J Am Chem Soc. 2002 Aug 21;124(33):9825-32. doi: 10.1021/ja0262333. J Am Chem Soc. 2002. PMID: 12175242

5

Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F.

Lee CB, Wu Z, Zhang F, Chappell MD, Stachel SJ, Chou TC, Guan Y, Danishefsky SJ. Lee CB, et al. Among authors: chappell md. J Am Chem Soc. 2001 Jun 6;123(22):5249-59. doi: 10.1021/ja010039j. J Am Chem Soc. 2001. PMID: 11457387

6

On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments.

Stachel SJ, Chappell MD, Lee CB, Danishefsky SJ, Chou TC, He L, Horwitz SB. Stachel SJ, et al. Among authors: chappell md. Org Lett. 2000 Jun 1;2(11):1637-9. doi: 10.1021/ol005932m. Org Lett. 2000. PMID: 10841498

7

Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21.

Lee CB, Chou TC, Zhang XG, Wang ZG, Kuduk SD, Chappell MD, Stachel SJ, Danishefsky SJ. Lee CB, et al. Among authors: chappell md. J Org Chem. 2000 Oct 6;65(20):6525-33. doi: 10.1021/jo000617z. J Org Chem. 2000. PMID: 11052097

8

On the interactivity of complex synthesis and tumor pharmacology in the drug discovery process: total synthesis and comparative in vivo evaluations of the 15-aza epothilones.

Stachel SJ, Lee CB, Spassova M, Chappell MD, Bornmann WG, Danishefsky SJ, Chou TC, Guan Y. Stachel SJ, et al. Among authors: chappell md. J Org Chem. 2001 Jun 15;66(12):4369-78. doi: 10.1021/jo010275c. J Org Chem. 2001. PMID: 11397179

9

En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B.

Chappell MD, Stachel SJ, Lee CB, Danishefsky SJ. Chappell MD, et al. Org Lett. 2000 Jun 1;2(11):1633-6. doi: 10.1021/ol0059302. Org Lett. 2000. PMID: 10841497

10

Synthesis of a six-carbon sialic acid using an indium-mediated coupling.

Chappell MD, Halcomb RL. Chappell MD, et al. Org Lett. 2000 Jul 13;2(14):2003-5. doi: 10.1021/ol990320r. Org Lett. 2000. PMID: 10891215

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